Co（III）通过C-H键活化催化2-吡啶酮与二烯和甲醛的三组分组装

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-03-24 DOI:10.1021/acs.orglett.5c00487

Priyambada Prusty, Masilamani Jeganmohan

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引用次数: 0

摘要

在这里，我们通过三组分顺序反应证明了Co（III）催化的取代吡啶酮与二烯和多聚甲醛的C-H功能化。合成了具有高区域选择性和化学选择性的同丙烯醇库。反应范围广泛兼容各种取代n -吡啶-2-吡啶酮、丁二烯、取代二烯。有趣的是，n -吡啶-4-吡啶酮也参与了反应。合成产物进一步转化为二氢呋喃衍生的n-吡啶-2-吡啶酮衍生物。描述了一个令人信服的机制和机械调查来证明目前的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Co(III)-Catalyzed Three-Component Assembling of 2-Pyridones with Dienes and Formaldehyde via C–H Bond Activation

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Co(III)-Catalyzed Three-Component Assembling of 2-Pyridones with Dienes and Formaldehyde via C–H Bond Activation

Here, we have demonstrated a Co(III)-catalyzed C–H functionalization of substituted pyridones with dienes and para-formaldehyde via a three-component sequential reaction. A library of homoallylic alcohols is synthesized with high regio- and chemoselectivity. The reaction scope is widely compatible with various substituted N-pyridyl-2-pyridones, butadiene, and substituted dienes. Interestingly, N-pyridyl-4-pyridone also participated in the reaction. The synthesized product was further converted into dihydrofuran-derived N-pyridyl-2-pyridone derivatives. A convincing mechanism and mechanistic investigations are described to justify the current methodology.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.