粉末状药物组合物喷雾干燥中分散的实验研究与建模

IF 0.7 4区工程技术 Q4 ENGINEERING, CHEMICAL

Theoretical Foundations of Chemical Engineering Pub Date : 2025-03-23 DOI:10.1134/S0040579525601025

E. A. Lebedev, N. V. Menshutina

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引用次数: 0

摘要

本文介绍了用于生产吸入用干粉药品的喷雾干燥技术的理论和实验研究。对雾化气流在气动喷油器喷嘴内和喷嘴周围的流动进行了数值模拟，并以此确定了雾化过程的关键参数，即雾化气流相对于进料速度的速度。确定了允许雾化空气速度的范围以及该参数对所产生颗粒大小的影响。在此基础上，提出了一种平均粒径为2.6 μ m、分布在1 ~ 4 μ m范围内的微颗粒制备方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Experimental Study and Modeling of Dispersion in Spray Drying for Producing Powdered Pharmaceutical Compositions

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Experimental Study and Modeling of Dispersion in Spray Drying for Producing Powdered Pharmaceutical Compositions

The paper presents theoretical and experimental studies of spray drying technology for the production of dry powder pharmaceuticals for inhalation use. A numerical simulation of atomizing air flows in and around a pneumatic injector nozzle is presented and is then used to determine the key parameters of the atomizing process, namely, the atomizing air velocity relative to the liquid feed velocity. The range of permissible atomizing air velocities and the influence of this parameter on the size of the resulting particles are determined. Based on the obtained modeling results, a method for producing microparticles with an average size of 2.6 µm and a distribution from 1 to 4 µm is proposed.

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来源期刊

Theoretical Foundations of Chemical Engineering 工程技术-工程：化工

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

24 months

期刊介绍： Theoretical Foundations of Chemical Engineering is a comprehensive journal covering all aspects of theoretical and applied research in chemical engineering, including transport phenomena; surface phenomena; processes of mixture separation; theory and methods of chemical reactor design; combined processes and multifunctional reactors; hydromechanic, thermal, diffusion, and chemical processes and apparatus, membrane processes and reactors; biotechnology; dispersed systems; nanotechnologies; process intensification; information modeling and analysis; energy- and resource-saving processes; environmentally clean processes and technologies.