在世界卫生组织非洲地区建立 COVID-19 疫苗有效性研究的挑战和促进因素:对非洲地区疫苗有效性监测(AFRO-MoVE)网络的混合方法评估。

Adam W Crawley, Katherine Murphy, Ian D Plumb, Grace Adjoa Ocansey, Isaac Baffoe-Nyarko, Norman Nyazema, Sibongile Walaza, Eva Leidman
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引用次数: 0

摘要

背景:非洲区域疫苗有效性监测网络(AFRO-MoVE)由世界卫生组织非洲区域办事处于2021年3月建立,以支持在该区域开展COVID-19疫苗有效性研究。目的:评价的主要目标是评估AFRO-MoVE如何实现其支持区域疫苗有效性(VE)研究的目标,描述挑战和机遇,并提出建议以加强与区域疫苗有效性研究相关的未来努力。方法:从2023年9月至2024年6月,采用混合方法综合信息:(1)AFRO-MoVE提供的文献;(2)标准化的学习回顾工具;(3)电子利益相关者调查;(4)一系列关键线人访谈。数据通过REDCap收集和导出,并使用Microsoft Excel进行汇总。采用主题分析法对定性数据进行分析。感知到的挑战与网络在解决每个挑战时的感知支持一起总结。结果:AFRO-MoVE为10项VE研究提供了支持,包括协议制定、研究实施、数据管理和分析,同时也促进了研究实施人员之间的知识交流和经验分享。虽然答复者报告说,在这些地区的国家和区域层面加强了VE研究的能力,但由于在2022年中期启动了许多研究,网络国家报告的病例有所减少,因此招募SARS-CoV-2阳性病例具有挑战性。这些挑战导致缺乏及时公布的来自网络研究站点的VE估计,无法为疫苗政策提供信息。结论:非洲行动组织的技术援助和财政支持得到网络成员的积极评价,并有助于提高在该区域进行VE研究的能力。研究结果的发表将进一步加强网络的影响。这些发现强调了加强快速产生免疫球蛋白的能力和支持防范未来大流行病的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Challenges and enablers to establishing COVID-19 vaccine effectiveness studies in the World Health Organization Africa region: A mixed-methods evaluation of the African region monitoring vaccine effectiveness (AFRO-MoVE) network.

Background: The African Region Monitoring Vaccine Effectiveness network (AFRO-MoVE) was established by the World Health Organization Regional Office for Africa in March 2021 to support implementation of COVID-19 vaccine effectiveness studies in the region.

Objectives: Primary goals of the evaluation were to assess how AFRO-MoVE addressed its objectives supporting regional vaccine effectiveness (VE) studies, to describe challenges and opportunities, and make recommendations to strengthen future efforts related to regional VE research.

Methods: From September 2023 through June 2024, a mixed-methods approach was employed to synthesize information from: (1) documentation provided by AFRO-MoVE; (2) a standardized study review tool; (3) an electronic stakeholder survey; and (4) a series of key informant interviews. Data were collected and exported via REDCap and summarized using Microsoft Excel. Thematic analysis was used to analyse the qualitative data. Perceived challenges were summarized together with perceived support by the network in addressing each challenge.

Results: AFRO-MoVE provided support to ten VE studies, including support for protocol development, study implementation, data management, and analysis, while also facilitating knowledge exchange and experience sharing among study implementers. While respondents reported strengthened capacity for VE studies at the national and regional levels in these areas, enrollment of SARS-CoV-2 positive cases was challenging, due to a decline in reported cases in network countries in mid-2022, when many studies were launched. These challenges contributed to a lack of published VE estimates from network study sites in time to inform vaccine policy.

Conclusion: AFRO-MoVE technical assistance and financial support was viewed positively by network members and contributed to increased capacity for conducting VE studies in the region. Publication of study results would further bolster the impact of the network. These finding underscore opportunities to enhance capacity for rapid VE generation and support preparedness for future pandemics.

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