虚拟现实技术可提高健康成年人的疼痛阈值和回忆能力：一项随机交叉研究。

IF 5 2区医学 Q1 ANESTHESIOLOGY

Journal of Clinical Anesthesia Pub Date : 2025-03-21 DOI:10.1016/j.jclinane.2025.111816

Samuel T. Rodriguez MD , Ricardo T. Jimenez BA , Ellen Y. Wang MD , Michelle Zuniga-Hernandez BS , Janet Titzler BS , Christian Jackson BS , Man Yee Suen MMedSci , Craig Yamaguchi BS , Brian Ko , Jiang-Ti Kong MD , Thomas J. Caruso MD, PhD

{"title":"虚拟现实技术可提高健康成年人的疼痛阈值和回忆能力：一项随机交叉研究。","authors":"Samuel T. Rodriguez MD , Ricardo T. Jimenez BA , Ellen Y. Wang MD , Michelle Zuniga-Hernandez BS , Janet Titzler BS , Christian Jackson BS , Man Yee Suen MMedSci , Craig Yamaguchi BS , Brian Ko , Jiang-Ti Kong MD , Thomas J. Caruso MD, PhD","doi":"10.1016/j.jclinane.2025.111816","DOIUrl":null,"url":null,"abstract":"<div><h3>Study objective</h3><div>Virtual reality (VR) is an emerging technology increasingly used to ameliorate acute and chronic pain although controlled, quantifiable data are limited. The purpose of this study is to evaluate VR's effect on heat pain threshold (HPT), pressure pain threshold (PPT), immediate pain and anxiety, and recalled pain and anxiety.</div></div><div><h3>Design</h3><div>Prospective, randomized, crossover clinical trial.</div></div><div><h3>Setting</h3><div>The Stanford Chariot Program conducted this study at the Stanford School of Medicine Health System.</div></div><div><h3>Patients</h3><div>Healthy participants meeting inclusion criteria were recruited by solicitation from the Stanford School of Medicine Health System.</div></div><div><h3>Interventions</h3><div>Participants were randomized by hand dominance and condition sequence and underwent standardized pain threshold tests with a thermode or an algometer during VR and control conditions.</div></div><div><h3>Measurements</h3><div>Pain threshold, numeric pain scores, and anxiety scores were immediately recorded. Recalled pain and anxiety scores were recorded 24 h later.</div></div><div><h3>Main results</h3><div>A total of 80 participants were included, 40 who underwent HPT testing and 40 who underwent PPT testing. VR increased pain thresholds for both HPT (<em>P</em> <em>=</em> 0.002) and PPT (<em>P</em> <em>=</em> 0.044). The use of VR resulted in no difference in initial pain scores for HPT (<em>P</em> <em>=</em> 0.432) or PPT (<em>P</em> <em>=</em> 0.24). There was no difference in recalled pain when using VR for HPT (<em>P</em> <em>=</em> 0.851) although there was for PPT (<em>P</em> <em>=</em> 0.003). Initial and recalled anxiety scores for HPT (<em>P</em> <em>=</em> 0.006, <em>P</em> <em>=</em> 0.018, respectively) and PPT (<em>P</em> <em>=</em> 0.014, <em>P</em> <em>=</em> 0.002, respectively) were all reduced when using VR.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that VR increased pain thresholds while modulating initial and recalled experiences with anxiety, which has implications for enhancing patient experiences during medical interventions and long-term health outcomes by optimizing memories during stressful events.</div><div>Clinical trial registration: <span><span>NCT05836649</span><svg><path></path></svg></span>, 4/19/23.</div><div>IRB registration: Stanford IRB #69330.</div></div>","PeriodicalId":15506,"journal":{"name":"Journal of Clinical Anesthesia","volume":"103 ","pages":"Article 111816"},"PeriodicalIF":5.0000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Virtual reality improves pain threshold and recall in healthy adults: A randomized, crossover study\",\"authors\":\"Samuel T. Rodriguez MD , Ricardo T. Jimenez BA , Ellen Y. Wang MD , Michelle Zuniga-Hernandez BS , Janet Titzler BS , Christian Jackson BS , Man Yee Suen MMedSci , Craig Yamaguchi BS , Brian Ko , Jiang-Ti Kong MD , Thomas J. Caruso MD, PhD\",\"doi\":\"10.1016/j.jclinane.2025.111816\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Study objective</h3><div>Virtual reality (VR) is an emerging technology increasingly used to ameliorate acute and chronic pain although controlled, quantifiable data are limited. The purpose of this study is to evaluate VR's effect on heat pain threshold (HPT), pressure pain threshold (PPT), immediate pain and anxiety, and recalled pain and anxiety.</div></div><div><h3>Design</h3><div>Prospective, randomized, crossover clinical trial.</div></div><div><h3>Setting</h3><div>The Stanford Chariot Program conducted this study at the Stanford School of Medicine Health System.</div></div><div><h3>Patients</h3><div>Healthy participants meeting inclusion criteria were recruited by solicitation from the Stanford School of Medicine Health System.</div></div><div><h3>Interventions</h3><div>Participants were randomized by hand dominance and condition sequence and underwent standardized pain threshold tests with a thermode or an algometer during VR and control conditions.</div></div><div><h3>Measurements</h3><div>Pain threshold, numeric pain scores, and anxiety scores were immediately recorded. Recalled pain and anxiety scores were recorded 24 h later.</div></div><div><h3>Main results</h3><div>A total of 80 participants were included, 40 who underwent HPT testing and 40 who underwent PPT testing. VR increased pain thresholds for both HPT (<em>P</em> <em>=</em> 0.002) and PPT (<em>P</em> <em>=</em> 0.044). The use of VR resulted in no difference in initial pain scores for HPT (<em>P</em> <em>=</em> 0.432) or PPT (<em>P</em> <em>=</em> 0.24). There was no difference in recalled pain when using VR for HPT (<em>P</em> <em>=</em> 0.851) although there was for PPT (<em>P</em> <em>=</em> 0.003). Initial and recalled anxiety scores for HPT (<em>P</em> <em>=</em> 0.006, <em>P</em> <em>=</em> 0.018, respectively) and PPT (<em>P</em> <em>=</em> 0.014, <em>P</em> <em>=</em> 0.002, respectively) were all reduced when using VR.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that VR increased pain thresholds while modulating initial and recalled experiences with anxiety, which has implications for enhancing patient experiences during medical interventions and long-term health outcomes by optimizing memories during stressful events.</div><div>Clinical trial registration: <span><span>NCT05836649</span><svg><path></path></svg></span>, 4/19/23.</div><div>IRB registration: Stanford IRB #69330.</div></div>\",\"PeriodicalId\":15506,\"journal\":{\"name\":\"Journal of Clinical Anesthesia\",\"volume\":\"103 \",\"pages\":\"Article 111816\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-03-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Anesthesia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0952818025000765\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ANESTHESIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Anesthesia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952818025000765","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

研究目的：虚拟现实（VR）是一项新兴技术，越来越多地用于改善急性和慢性疼痛，尽管控制，可量化的数据有限。本研究的目的是评估VR对热痛阈（HPT）、压痛阈（PPT）、即时疼痛和焦虑以及回忆性疼痛和焦虑的影响。设计：前瞻性、随机、交叉临床试验。环境：斯坦福战车项目在斯坦福医学院卫生系统进行了这项研究。患者：符合纳入标准的健康参与者由斯坦福医学院卫生系统征集而来。干预措施：参与者按手优势和条件顺序随机分组，并在VR和控制条件下使用热模或测痛仪进行标准化痛阈测试。测量方法：立即记录疼痛阈值、数值疼痛评分和焦虑评分。24小时后记录疼痛和焦虑的回忆评分。主要结果：共纳入80例受试者，其中HPT测试40例，PPT测试40例。VR提高了HPT （P = 0.002）和PPT （P = 0.044）的痛阈。VR的使用导致HPT （P = 0.432）或PPT （P = 0.24）的初始疼痛评分无差异。在HPT中使用VR时，回忆疼痛没有差异（P = 0.851），而PPT中有差异（P = 0.003）。使用VR后，HPT （P = 0.006, P = 0.018）和PPT （P = 0.014, P = 0.002）的初始和回忆焦虑得分均降低。结论：本研究表明，VR增加了疼痛阈值，同时调节了焦虑的初始和回忆经历，这对通过优化压力事件中的记忆来增强患者在医疗干预期间的体验和长期健康结果具有重要意义。临床试验注册：NCT05836649, 4/19/23。IRB注册：Stanford IRB #69330。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Virtual reality improves pain threshold and recall in healthy adults: A randomized, crossover study

Study objective

Virtual reality (VR) is an emerging technology increasingly used to ameliorate acute and chronic pain although controlled, quantifiable data are limited. The purpose of this study is to evaluate VR's effect on heat pain threshold (HPT), pressure pain threshold (PPT), immediate pain and anxiety, and recalled pain and anxiety.

Design

Prospective, randomized, crossover clinical trial.

Setting

The Stanford Chariot Program conducted this study at the Stanford School of Medicine Health System.

Patients

Healthy participants meeting inclusion criteria were recruited by solicitation from the Stanford School of Medicine Health System.

Interventions

Participants were randomized by hand dominance and condition sequence and underwent standardized pain threshold tests with a thermode or an algometer during VR and control conditions.

Measurements

Pain threshold, numeric pain scores, and anxiety scores were immediately recorded. Recalled pain and anxiety scores were recorded 24 h later.

Main results

A total of 80 participants were included, 40 who underwent HPT testing and 40 who underwent PPT testing. VR increased pain thresholds for both HPT (P = 0.002) and PPT (P = 0.044). The use of VR resulted in no difference in initial pain scores for HPT (P = 0.432) or PPT (P = 0.24). There was no difference in recalled pain when using VR for HPT (P = 0.851) although there was for PPT (P = 0.003). Initial and recalled anxiety scores for HPT (P = 0.006, P = 0.018, respectively) and PPT (P = 0.014, P = 0.002, respectively) were all reduced when using VR.

Conclusions

This study demonstrates that VR increased pain thresholds while modulating initial and recalled experiences with anxiety, which has implications for enhancing patient experiences during medical interventions and long-term health outcomes by optimizing memories during stressful events.

Clinical trial registration: NCT05836649, 4/19/23.

IRB registration: Stanford IRB #69330.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Clinical Anesthesia 医学-麻醉学

CiteScore

7.40

自引率

4.50%

发文量

346

审稿时长

23 days

期刊介绍： The Journal of Clinical Anesthesia (JCA) addresses all aspects of anesthesia practice, including anesthetic administration, pharmacokinetics, preoperative and postoperative considerations, coexisting disease and other complicating factors, cost issues, and similar concerns anesthesiologists contend with daily. Exceptionally high standards of presentation and accuracy are maintained. The core of the journal is original contributions on subjects relevant to clinical practice, and rigorously peer-reviewed. Highly respected international experts have joined together to form the Editorial Board, sharing their years of experience and clinical expertise. Specialized section editors cover the various subspecialties within the field. To keep your practical clinical skills current, the journal bridges the gap between the laboratory and the clinical practice of anesthesiology and critical care to clarify how new insights can improve daily practice.