同卵和异卵双胞胎儿童过敏进展的前瞻性临床研究。

IF 1.5 4区 医学 Q2 PEDIATRICS
Translational pediatrics Pub Date : 2025-02-28 Epub Date: 2025-02-25 DOI:10.21037/tp-2024-615
Jing Wang, Li Wang, Shuang Liu, Yuling Han, Darryl J Adamko, Lu Cheng, Jingjing Gao, Yun Zhang, Xiang Ma, Aihua Cao
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引用次数: 0

摘要

背景:了解导致过敏性疾病发展的因素是一个重要的研究领域。我们研究了同卵双胞胎和异卵双胞胎过敏性疾病的发展,以确定环境因素与遗传因素的潜在差异。方法:选择4岁以下的双胞胎进行长期随访研究。检查常规问卷调查结果、过敏原水平和其他指标。结果:本研究共纳入80对双胞胎。随着时间的推移,特应性皮炎(AD)的发病率下降,鼻炎和喘息的发病率增加。同卵双胞胎患AD、鼻炎和食物过敏的几率明显高于异卵双胞胎。同卵双胞胎吸入过敏原阳性和食物过敏原阳性浓度明显高于异卵双胞胎。分析变态反应性疾病的影响因素。在同卵双胞胎中,与出生体重相近的男性更易患AD。结论:儿童过敏性疾病具有较强的遗传易感性,但也受环境因素的影响。影响异卵双胞胎过敏性疾病发生的环境因素不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A prospective clinical study of allergy progression in identical and fraternal twin pairs of children.

Background: Understanding the factors leading to the development of allergic disease is a critical area of research. We studied the development of allergic disease in identical and fraternal twins to identify potential differences in environment versus genetic factors.

Methods: Twins aged up to 4 years were selected for inclusion in this long-term follow-up study. Regular questionnaire results, allergen levels, and other indicators were examined.

Results: A total of 80 twins were included in this study. Over time, the incidence of atopic dermatitis (AD) decreased, and the incidence of rhinitis and wheezing increased. The incidence of AD, rhinitis, and food allergy was significantly higher in identical twins than fraternal twins. The consistency of positive inhaled allergens and positive food allergens was significantly higher in the identical twins than fraternal twins. The factors influencing allergic diseases were analyzed. In the identical twins, AD was more frequent in males, those with a birth weight <2,500 g, and having siblings; rhinitis was more frequent in those living in a bungalow style home, having pets, and carpeting; and wheezing was more frequent in males, having a birth weight <2,500 g, and having siblings. In the fraternal twins, AD was more frequent in those born <37 weeks gestation, and having flowers and plants in the house; rhinitis was more frequent in those born <37 weeks gestation, those with a history of neonatal asphyxia, and having a household smoking; and wheezing was more frequent in those born <37 weeks gestation, those with a history of neonatal asphyxia, with central heating, and household smoking. No factors were found to affect the occurrence of food allergy.

Conclusions: Allergic diseases in children have a strong genetic predisposition, but are also influenced by environmental factors. The environmental factors affecting the occurrence of allergic diseases in identical and fraternal twins differ.

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来源期刊
Translational pediatrics
Translational pediatrics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
4.50
自引率
5.00%
发文量
108
期刊介绍: Information not localized
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