结直肠癌后结直肠癌和结外癌的风险:系统回顾和荟萃分析。

IF 4.1 Q2 ONCOLOGY
Ye Kyaw Aung, Ye Zhang, Mark A Jenkins, Aung Ko Win
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引用次数: 0

摘要

背景:结直肠癌幸存者在结直肠和其他解剖部位发生新的原发癌症的风险增加。本系统综述旨在评估结直肠癌后原发性结直肠癌和结外癌的风险。方法:在四个数据库中筛选2025年1月之前发表的同行评议文章,以确定使用人口癌症登记处报告结直肠癌后原发性癌症标准化发病率(SIRs)的研究,并与普通人群进行比较。我们进行了一项荟萃分析来总结SIRs,并使用总结的SIRs和年龄、性别、日历、地区和癌症特异性发病率数据来估计结直肠癌后原发性癌症的年龄特异性累积风险。结果:8254篇文献中,57篇纳入meta分析。原发性癌症、结肠外癌和结直肠癌的合并SIRs(95%置信区间)分别为1.13(1.06-1.20)、1.10(1.03-1.17)和1.55(1.33-1.77)。在最近的研究中,还观察到原发性肠癌、卵巢癌、子宫癌、睾丸癌、肾癌、女性乳腺癌、甲状腺癌和前列腺癌以及肺癌和膀胱癌的风险增加。到75岁,任何原发性癌症、结肠外癌和结直肠癌的累积风险分别为:澳大利亚的38.5%、31.6%和8.24%;北美占33.8%、30.9%和4.77%;东亚分别为27.4%、25.6%和8.01%;欧洲为33.4%、28.8%和4.68%。结论:与普通人群相比,结直肠癌幸存者患结肠外和结直肠癌的风险增加。这些发现强调了有必要制定针对性的监测和预防策略,以有效识别和管理这一人群随后的原发性癌症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Risks of colorectal and extracolonic cancers following colorectal cancer: a systematic review and meta-analysis.

Risks of colorectal and extracolonic cancers following colorectal cancer: a systematic review and meta-analysis.

Risks of colorectal and extracolonic cancers following colorectal cancer: a systematic review and meta-analysis.

Risks of colorectal and extracolonic cancers following colorectal cancer: a systematic review and meta-analysis.

Background: Colorectal cancer survivors face increased risks of developing new primary cancers in colorectum and other anatomical sites. This systematic review aimed to estimate primary colorectal and extracolonic cancers risks following colorectal cancer.

Methods: Peer-reviewed articles published before January 2025 were screened across 4 databases to identify studies using population cancer registry reporting standardized incidence ratios (SIRs) of primary cancers following colorectal cancer, compared with the general population. A meta-analysis was conducted to summarize the SIRs, and age-specific cumulative risks of primary cancers following colorectal cancer were estimated using the summarized SIRs and age-, sex-, calendar-, region-, and cancer-specific incidence data.

Results: Of 8254 articles identified, 57 were included in meta-analysis. The pooled SIRs (95% confidence interval) for any primary cancer, extracolonic cancer and colorectal cancer were 1.13 (1.06 to 1.20), 1.10 (1.03 to 1.17), and 1.55 (1.33 to 1.77), respectively. Increased risks were also observed for primary cancers of small intestine, ovary, uterus, testes, kidney, female breast, thyroid, and prostate overall, as well as for lung and urinary bladder cancer in recent studies. The cumulative risks of any primary cancer, extracolonic cancer, and colorectal cancer to age 75 years were 38.5%, 31.6%, and 8.24% in Australasia; 33.8%, 30.9%, and 4.77% in North America; 27.4%, 25.6%, and 8.01% in East Asia; and 33.4%, 28.8%, and 4.68% in Europe.

Conclusion: Colorectal cancer survivors have an increased risk of subsequent primary cancers, both extracolonic and colorectal, when compared with the general population. These findings underscore the necessity for tailored surveillance and prevention strategies to effectively identify and manage subsequent primary cancers in this population.

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来源期刊
JNCI Cancer Spectrum
JNCI Cancer Spectrum Medicine-Oncology
CiteScore
7.70
自引率
0.00%
发文量
80
审稿时长
18 weeks
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