{"title":"胰岛素抵抗相关的灰质体积减少与默认模式网络有关","authors":"Saki Asano, Akitoshi Ogawa, Takahiro Osada, Satoshi Oka, Koji Nakajima, Yasushi Oshima, Sakae Tanaka, Hideyoshi Kaga, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Seiki Konishi","doi":"10.14789/ejmj.JMJ24-0044-OT","DOIUrl":null,"url":null,"abstract":"<p><p>In this study, we observed that insulin resistance is linked to a reduction in grey matter volume in the default-mode and limbic networks of the cerebral cortex in older adults. Additionally, we found that the paraventricular nucleus of the hypothalamus is significantly functionally connected to these two cortical networks. Our results suggest that the reduction in gray matter volume associated with insulin resistance arises through metabolic homeostasis mechanisms in the hypothalamus.</p>","PeriodicalId":520470,"journal":{"name":"Juntendo medical journal","volume":"71 1","pages":"32-35"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915748/pdf/","citationCount":"0","resultStr":"{\"title\":\"Insulin Resistance-related Gray Matter Volume Reduction is Associated with the Default Mode Network.\",\"authors\":\"Saki Asano, Akitoshi Ogawa, Takahiro Osada, Satoshi Oka, Koji Nakajima, Yasushi Oshima, Sakae Tanaka, Hideyoshi Kaga, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Seiki Konishi\",\"doi\":\"10.14789/ejmj.JMJ24-0044-OT\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this study, we observed that insulin resistance is linked to a reduction in grey matter volume in the default-mode and limbic networks of the cerebral cortex in older adults. Additionally, we found that the paraventricular nucleus of the hypothalamus is significantly functionally connected to these two cortical networks. Our results suggest that the reduction in gray matter volume associated with insulin resistance arises through metabolic homeostasis mechanisms in the hypothalamus.</p>\",\"PeriodicalId\":520470,\"journal\":{\"name\":\"Juntendo medical journal\",\"volume\":\"71 1\",\"pages\":\"32-35\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915748/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Juntendo medical journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14789/ejmj.JMJ24-0044-OT\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Juntendo medical journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14789/ejmj.JMJ24-0044-OT","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Insulin Resistance-related Gray Matter Volume Reduction is Associated with the Default Mode Network.
In this study, we observed that insulin resistance is linked to a reduction in grey matter volume in the default-mode and limbic networks of the cerebral cortex in older adults. Additionally, we found that the paraventricular nucleus of the hypothalamus is significantly functionally connected to these two cortical networks. Our results suggest that the reduction in gray matter volume associated with insulin resistance arises through metabolic homeostasis mechanisms in the hypothalamus.
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