IF 4.4 1区 医学 Q1 ORTHOPEDICS
Danielle Dagher, Imad Kashir, Osman Mahboob, Nasser Al-Turki, Moin Khan
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引用次数: 0

摘要

目的:本系统性综述旨在评估氨甲环酸(TXA)与安慰剂或其他对比药物相比,对肩关节镜手术患者的视觉清晰度、疼痛、总手术时间和失血量的影响:方法:检索了从开始到 2025 年 1 月 4 日的 CENTRAL、EMBASE 和 MEDLINE。研究选择和数据提取一式两份。纳入了对接受肩关节镜手术的患者进行TXA与安慰剂或其他对比试验比较的随机对照试验。所有结果均采用RoB-2工具进行偏倚风险(RoB)评估,并采用GRADE(推荐、评估、发展和评价分级)方法进行证据确定性评估。在适当的情况下,使用随机效应模型对结果进行荟萃分析;在无法对数据进行荟萃分析时,则对结果进行叙述性综合:结果:共纳入了 12 项随机对照试验,涉及 1009 名患者。视觉清晰度的汇总估计值显示,视觉清晰度略有提高(标准化平均差为 0.64 [0.05, 1.24])。疼痛的汇总估计值显示,在视觉模拟量表 0 至 10 分(0 = 无痛)中,TXA 组的疼痛平均减轻 0.38 分(平均差 -0.38 [-0.76, 0.00]):中度确定性证据表明,TXA 可使视觉清晰度略有提高。证据还表明,TXA 对疼痛、手术时间和失血量几乎没有影响:一级,一级研究的系统回顾。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tranexamic Acid Has A Limited Role in Improving Visual Clarity and Pain in Arthroscopic Shoulder Surgery: A Systematic Review and Meta-Analysis.

Purpose: The purpose of this systematic review was to evaluate the effects of tranexamic acid (TXA) compared to placebo or other comparators with regard to visual clarity, pain, total operative time, and volume of blood loss in patients undergoing arthroscopic shoulder surgery.

Methods: CENTRAL, EMBASE, and MEDLINE were searched from inception until January 4th, 2025. Study selection and data extraction were carried out in duplicate. Randomized controlled trials that compared TXA versus placebo or another comparator in patients undergoing arthroscopic shoulder surgery were included. All outcomes were assessed in duplicate for risk of bias (RoB) using the RoB-2 tool and for certainty of evidence using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) approach. Results were pooled in a meta-analysis using a random-effects model when appropriate or were synthesized narratively when data could not be pooled.

Results: Overall, 12 randomized controlled trials involving 1009 patients were included. The pooled estimate for visual clarity shows a slight increase in visual clarity (Standardized Mean Difference 0.64 [0.05, 1.24]). The pooled estimate for pain shows a mean difference of a reduction of pain by 0.38 points in the TXA group on a visual analog scale of 0 to 10 (0 = no pain) (Mean Difference -0.38 [-0.76, 0.00]).

Conclusions: There is moderate-certainty evidence suggesting that TXA likely results in a slight increase in visual clarity. The evidence also suggests that TXA has little to no difference in pain, operative time, and volume of blood loss.

Level of evidence: Level I, systematic review of Level I studies.

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来源期刊
CiteScore
9.30
自引率
17.00%
发文量
555
审稿时长
58 days
期刊介绍: Nowhere is minimally invasive surgery explained better than in Arthroscopy, the leading peer-reviewed journal in the field. Every issue enables you to put into perspective the usefulness of the various emerging arthroscopic techniques. The advantages and disadvantages of these methods -- along with their applications in various situations -- are discussed in relation to their efficiency, efficacy and cost benefit. As a special incentive, paid subscribers also receive access to the journal expanded website.
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