{"title":"ZFAS1/miRNAs/ mrna轴在癌症中的调控作用：系统综述","authors":"Rahul Kumar Singh, Surojit Mandal, Adrija Mohanta, Ritu Yadav, Rajiv Ranjan Kumar, Rinku Khatkar, Vivek Uttam, Uttam Sharma, Manjit Kaur Rana, Manju Jain, Hardeep Singh Tuli, Aklank Jain","doi":"10.32604/or.2024.050548","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Recently, we and others have demonstrated the involvement of Zinc Finger Antisense 1 (<i>ZFAS1</i>) in cancer development. However, the intricate interplay of <i>ZFAS1</i> with miRNAs and mRNAs remains to be fully understood.</p><p><strong>Materials and methods: </strong>We followed PRISMA guidelines to retrieve and assess the available literature on the topic \"<i>ZFAS1</i>/miRNA/mRNA axis\" and \"Cancer\" from databases such as PubMed, Google Scholar, and ScienceDirect. We also used bioinformatic webtools for analyzing the potential miRNA targets of <i>ZFAS1</i> and its role in survival of cancer patients along with their role in various biological functions and pathways.</p><p><strong>Results: </strong>Our literature search and bioinformatic analysis reveals that <i>ZFAS1</i> serves as a sponge for numerous miRNAs. Among the various targeted miRNAs, miR-150-5p stands out as significantly correlated with <i>ZFAS1</i> across multiple databases (<i>p</i>-value = 3.27e-16, <i>R-</i>value = -0.346). Additionally, our Kaplan-Meier survival analysis indicates a noteworthy association between <i>ZFAS1</i> expression levels and overall poor prognosis and survival rates in ovarian, sarcoma, and pancreatic cancers. We also underscore the involvement of various signaling pathways, including Signal Transducer and Activator of Transcription 3 (STAT3), Spindle and Kinetochore-associated Protein 1 (SKA1), Lysophosphatidic acid receptor 1 (LPAR1), and Wnt β-catenin, in cancer development through the <i>ZFAS1</i>/miRNAs/mRNAs axis. Furthermore, we identify <i>ZFAS1</i>'s pivotal roles in diverse molecular processes, such as RNA binding and ribonucleoprotein formation.</p><p><strong>Conclusion: </strong>In conclusion, this review comprehensively summarizes the latest advancements in understanding the regulatory relationships among <i>ZFAS1</i>, miRNAs, and mRNAs, emphasizing their collective role in cancer development to propose innovative avenues for cancer treatment. We believe that the intricate relationship among the <i>ZFAS1</i>-miRNA-mRNA axis may yield potential therapeutic targets for effective cancer management.</p>","PeriodicalId":19537,"journal":{"name":"Oncology Research","volume":"33 3","pages":"591-604"},"PeriodicalIF":2.0000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915068/pdf/","citationCount":"0","resultStr":"{\"title\":\"The regulatory role of <i>ZFAS1/</i>miRNAs/mRNAs axis in cancer: a systematic review.\",\"authors\":\"Rahul Kumar Singh, Surojit Mandal, Adrija Mohanta, Ritu Yadav, Rajiv Ranjan Kumar, Rinku Khatkar, Vivek Uttam, Uttam Sharma, Manjit Kaur Rana, Manju Jain, Hardeep Singh Tuli, Aklank Jain\",\"doi\":\"10.32604/or.2024.050548\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Recently, we and others have demonstrated the involvement of Zinc Finger Antisense 1 (<i>ZFAS1</i>) in cancer development. However, the intricate interplay of <i>ZFAS1</i> with miRNAs and mRNAs remains to be fully understood.</p><p><strong>Materials and methods: </strong>We followed PRISMA guidelines to retrieve and assess the available literature on the topic \\\"<i>ZFAS1</i>/miRNA/mRNA axis\\\" and \\\"Cancer\\\" from databases such as PubMed, Google Scholar, and ScienceDirect. We also used bioinformatic webtools for analyzing the potential miRNA targets of <i>ZFAS1</i> and its role in survival of cancer patients along with their role in various biological functions and pathways.</p><p><strong>Results: </strong>Our literature search and bioinformatic analysis reveals that <i>ZFAS1</i> serves as a sponge for numerous miRNAs. Among the various targeted miRNAs, miR-150-5p stands out as significantly correlated with <i>ZFAS1</i> across multiple databases (<i>p</i>-value = 3.27e-16, <i>R-</i>value = -0.346). Additionally, our Kaplan-Meier survival analysis indicates a noteworthy association between <i>ZFAS1</i> expression levels and overall poor prognosis and survival rates in ovarian, sarcoma, and pancreatic cancers. We also underscore the involvement of various signaling pathways, including Signal Transducer and Activator of Transcription 3 (STAT3), Spindle and Kinetochore-associated Protein 1 (SKA1), Lysophosphatidic acid receptor 1 (LPAR1), and Wnt β-catenin, in cancer development through the <i>ZFAS1</i>/miRNAs/mRNAs axis. Furthermore, we identify <i>ZFAS1</i>'s pivotal roles in diverse molecular processes, such as RNA binding and ribonucleoprotein formation.</p><p><strong>Conclusion: </strong>In conclusion, this review comprehensively summarizes the latest advancements in understanding the regulatory relationships among <i>ZFAS1</i>, miRNAs, and mRNAs, emphasizing their collective role in cancer development to propose innovative avenues for cancer treatment. We believe that the intricate relationship among the <i>ZFAS1</i>-miRNA-mRNA axis may yield potential therapeutic targets for effective cancer management.</p>\",\"PeriodicalId\":19537,\"journal\":{\"name\":\"Oncology Research\",\"volume\":\"33 3\",\"pages\":\"591-604\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915068/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oncology Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.32604/or.2024.050548\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oncology Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.32604/or.2024.050548","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
The regulatory role of ZFAS1/miRNAs/mRNAs axis in cancer: a systematic review.
Objectives: Recently, we and others have demonstrated the involvement of Zinc Finger Antisense 1 (ZFAS1) in cancer development. However, the intricate interplay of ZFAS1 with miRNAs and mRNAs remains to be fully understood.
Materials and methods: We followed PRISMA guidelines to retrieve and assess the available literature on the topic "ZFAS1/miRNA/mRNA axis" and "Cancer" from databases such as PubMed, Google Scholar, and ScienceDirect. We also used bioinformatic webtools for analyzing the potential miRNA targets of ZFAS1 and its role in survival of cancer patients along with their role in various biological functions and pathways.
Results: Our literature search and bioinformatic analysis reveals that ZFAS1 serves as a sponge for numerous miRNAs. Among the various targeted miRNAs, miR-150-5p stands out as significantly correlated with ZFAS1 across multiple databases (p-value = 3.27e-16, R-value = -0.346). Additionally, our Kaplan-Meier survival analysis indicates a noteworthy association between ZFAS1 expression levels and overall poor prognosis and survival rates in ovarian, sarcoma, and pancreatic cancers. We also underscore the involvement of various signaling pathways, including Signal Transducer and Activator of Transcription 3 (STAT3), Spindle and Kinetochore-associated Protein 1 (SKA1), Lysophosphatidic acid receptor 1 (LPAR1), and Wnt β-catenin, in cancer development through the ZFAS1/miRNAs/mRNAs axis. Furthermore, we identify ZFAS1's pivotal roles in diverse molecular processes, such as RNA binding and ribonucleoprotein formation.
Conclusion: In conclusion, this review comprehensively summarizes the latest advancements in understanding the regulatory relationships among ZFAS1, miRNAs, and mRNAs, emphasizing their collective role in cancer development to propose innovative avenues for cancer treatment. We believe that the intricate relationship among the ZFAS1-miRNA-mRNA axis may yield potential therapeutic targets for effective cancer management.
期刊介绍：
Oncology Research Featuring Preclinical and Clincal Cancer Therapeutics publishes research of the highest quality that contributes to an understanding of cancer in areas of molecular biology, cell biology, biochemistry, biophysics, genetics, biology, endocrinology, and immunology, as well as studies on the mechanism of action of carcinogens and therapeutic agents, reports dealing with cancer prevention and epidemiology, and clinical trials delineating effective new therapeutic regimens.
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