{"title":"电子闪光剂量测定和光束控制机制的系统回顾与改进的非临床LINACs。","authors":"Justin DeFrancisco, Siyong Kim","doi":"10.1002/acm2.70051","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>FLASH has been shown to spare normal tissue toxicity while maintaining tumor control. However, existing irradiation platforms and dosimetry are not compatible. Consequently, an abundance of FLASH delivery devices and new dosimetry across all modalities has been created. Many review articles concluded that dosimetry is modality-dependent. Focusing on electrons, researchers have modified clinical LINACs to enable FLASH dose rates. Modified LINACs caused the development of unique control systems that have yet to be characterized. Improvement could be made when considering the organization of reviews.</p>\n </section>\n \n <section>\n \n <h3> Purpose</h3>\n \n <p>To systematically perform a literature survey on electron FLASH dosimetry and beam control mechanisms with modified LINACs, detail where articles originated, and organize the results.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A literature survey was performed from two websites using specified keywords and sifted results to find articles that fit the criteria. The results were organized in tables and summaries effectively by matching up dosimeters with their measurement goal, referring to their specific models, outlining the irradiation conditions they were tested in, and detailing their calibration procedure. Furthermore, included was the unique topic of control mechanisms.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Twenty-eight matches were found. Various dosimeters were examined to measure absorbed dose, beam characteristics (BC), dose per pulse (DPP), and pulse counting (PC). Specific detectors and the irradiation conditions are organized and presented in a table. Each model's pros and cons are presented in another table for further consideration. A third table is provided to detail beam control methods.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Dosimetry is majorly film-based for absorbed dose and beam characteristic measurements. Many candidates for dosimeters for the use of DPP and PC have been tested, but they have yet to be tested without limitations. Beam control mechanisms primarily consist of unacceptable delivery errors. Many suggestions for improvement were given, mainly consisting of finding new dosimeters and modulating the dose DPP.</p>\n </section>\n </div>","PeriodicalId":14989,"journal":{"name":"Journal of Applied Clinical Medical Physics","volume":"26 4","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm2.70051","citationCount":"0","resultStr":"{\"title\":\"A systematic review of electron FLASH dosimetry and beam control mechanisms utilized with modified non-clinical LINACs\",\"authors\":\"Justin DeFrancisco, Siyong Kim\",\"doi\":\"10.1002/acm2.70051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>FLASH has been shown to spare normal tissue toxicity while maintaining tumor control. However, existing irradiation platforms and dosimetry are not compatible. Consequently, an abundance of FLASH delivery devices and new dosimetry across all modalities has been created. Many review articles concluded that dosimetry is modality-dependent. Focusing on electrons, researchers have modified clinical LINACs to enable FLASH dose rates. Modified LINACs caused the development of unique control systems that have yet to be characterized. Improvement could be made when considering the organization of reviews.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>To systematically perform a literature survey on electron FLASH dosimetry and beam control mechanisms with modified LINACs, detail where articles originated, and organize the results.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A literature survey was performed from two websites using specified keywords and sifted results to find articles that fit the criteria. The results were organized in tables and summaries effectively by matching up dosimeters with their measurement goal, referring to their specific models, outlining the irradiation conditions they were tested in, and detailing their calibration procedure. Furthermore, included was the unique topic of control mechanisms.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Twenty-eight matches were found. Various dosimeters were examined to measure absorbed dose, beam characteristics (BC), dose per pulse (DPP), and pulse counting (PC). Specific detectors and the irradiation conditions are organized and presented in a table. Each model's pros and cons are presented in another table for further consideration. A third table is provided to detail beam control methods.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Dosimetry is majorly film-based for absorbed dose and beam characteristic measurements. Many candidates for dosimeters for the use of DPP and PC have been tested, but they have yet to be tested without limitations. Beam control mechanisms primarily consist of unacceptable delivery errors. Many suggestions for improvement were given, mainly consisting of finding new dosimeters and modulating the dose DPP.</p>\\n </section>\\n </div>\",\"PeriodicalId\":14989,\"journal\":{\"name\":\"Journal of Applied Clinical Medical Physics\",\"volume\":\"26 4\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-03-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm2.70051\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Applied Clinical Medical Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/acm2.70051\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Clinical Medical Physics","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/acm2.70051","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
A systematic review of electron FLASH dosimetry and beam control mechanisms utilized with modified non-clinical LINACs
Background
FLASH has been shown to spare normal tissue toxicity while maintaining tumor control. However, existing irradiation platforms and dosimetry are not compatible. Consequently, an abundance of FLASH delivery devices and new dosimetry across all modalities has been created. Many review articles concluded that dosimetry is modality-dependent. Focusing on electrons, researchers have modified clinical LINACs to enable FLASH dose rates. Modified LINACs caused the development of unique control systems that have yet to be characterized. Improvement could be made when considering the organization of reviews.
Purpose
To systematically perform a literature survey on electron FLASH dosimetry and beam control mechanisms with modified LINACs, detail where articles originated, and organize the results.
Methods
A literature survey was performed from two websites using specified keywords and sifted results to find articles that fit the criteria. The results were organized in tables and summaries effectively by matching up dosimeters with their measurement goal, referring to their specific models, outlining the irradiation conditions they were tested in, and detailing their calibration procedure. Furthermore, included was the unique topic of control mechanisms.
Results
Twenty-eight matches were found. Various dosimeters were examined to measure absorbed dose, beam characteristics (BC), dose per pulse (DPP), and pulse counting (PC). Specific detectors and the irradiation conditions are organized and presented in a table. Each model's pros and cons are presented in another table for further consideration. A third table is provided to detail beam control methods.
Conclusions
Dosimetry is majorly film-based for absorbed dose and beam characteristic measurements. Many candidates for dosimeters for the use of DPP and PC have been tested, but they have yet to be tested without limitations. Beam control mechanisms primarily consist of unacceptable delivery errors. Many suggestions for improvement were given, mainly consisting of finding new dosimeters and modulating the dose DPP.
期刊介绍：
Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission.
JACMP will publish:
-Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500.
-Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed.
-Technical Notes: These should be no longer than 3000 words, including key references.
-Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents.
-Book Reviews: The editorial office solicits Book Reviews.
-Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics.
-Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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