{"title":"利用细胞外体积分数预测晚期胆囊癌的浸润模式。","authors":"Yukihisa Takayama, Takehiko Koga, Yoshihiro Hamada, Shinji Tanaka, Keisuke Sato, Ryo Murayama, Yusuke Ishida, Masatoshi Kajiwara, Kengo Yoshimitsu","doi":"10.1007/s11604-025-01768-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the utility of extracellular volume (ECV) fraction for predicting wall-invasion patterns in advanced gallbladder carcinoma (GBCA).</p><p><strong>Materials and methods: </strong>Patients who had surgically resected GBCA at a single institution were retrospectively evaluated. All patients underwent computed tomography (CT) before the surgery. Based on pathological examinations, the wall-invasion pattern of GBCA was classified into two groups: infiltrative growth (IG, n = 19) and destructive growth (DG, n = 11). ECV map was generated by inputting the patients' hematocrit values and subtraction algorithms using pre-contrast and equilibrium phase images. CT parameters were evaluated by two radiologists (Rad1 and Rad2). The Mann-Whitney U test was performed to identify significant CT parameters for differentiating between the two groups. The diagnostic ability was measured using receiver operating characteristic (ROC) curve analysis. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method, and differences between the two groups were compared using the log-rank test.</p><p><strong>Results: </strong>Thirty patients (mean age, 75.5 years; 20 men) were evaluated. Mean ECV fraction of the DG-type (Rad1, 34.5%; Rad2, 34.1%) was significantly higher than that of the IG-type (Rad1, 28.5%; Rad2, 28.8%) (p < 0.05). The ECV values of the two radiologists indicated that the areas under the ROC curves for differentiation between the two groups were Rad1, 0.91 and Rad2, 0.84 (p < 0.05). Medium RFS of the DG-type (970 days) was significantly shorter than that of the IG-type (2200 days) (p < 0.05).</p><p><strong>Conclusion: </strong>ECV fraction demonstrates potential as the most valuable predictor of the DG type of GBCA, which has a higher recurrence rate compared with the IG type. However, further large-scale multi-center studies are required to validate these findings.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1323-1334"},"PeriodicalIF":2.1000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287180/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prediction of the wall-invasion pattern of advanced gallbladder carcinoma using extracellular volume fraction.\",\"authors\":\"Yukihisa Takayama, Takehiko Koga, Yoshihiro Hamada, Shinji Tanaka, Keisuke Sato, Ryo Murayama, Yusuke Ishida, Masatoshi Kajiwara, Kengo Yoshimitsu\",\"doi\":\"10.1007/s11604-025-01768-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aimed to evaluate the utility of extracellular volume (ECV) fraction for predicting wall-invasion patterns in advanced gallbladder carcinoma (GBCA).</p><p><strong>Materials and methods: </strong>Patients who had surgically resected GBCA at a single institution were retrospectively evaluated. All patients underwent computed tomography (CT) before the surgery. Based on pathological examinations, the wall-invasion pattern of GBCA was classified into two groups: infiltrative growth (IG, n = 19) and destructive growth (DG, n = 11). ECV map was generated by inputting the patients' hematocrit values and subtraction algorithms using pre-contrast and equilibrium phase images. CT parameters were evaluated by two radiologists (Rad1 and Rad2). The Mann-Whitney U test was performed to identify significant CT parameters for differentiating between the two groups. The diagnostic ability was measured using receiver operating characteristic (ROC) curve analysis. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method, and differences between the two groups were compared using the log-rank test.</p><p><strong>Results: </strong>Thirty patients (mean age, 75.5 years; 20 men) were evaluated. Mean ECV fraction of the DG-type (Rad1, 34.5%; Rad2, 34.1%) was significantly higher than that of the IG-type (Rad1, 28.5%; Rad2, 28.8%) (p < 0.05). The ECV values of the two radiologists indicated that the areas under the ROC curves for differentiation between the two groups were Rad1, 0.91 and Rad2, 0.84 (p < 0.05). Medium RFS of the DG-type (970 days) was significantly shorter than that of the IG-type (2200 days) (p < 0.05).</p><p><strong>Conclusion: </strong>ECV fraction demonstrates potential as the most valuable predictor of the DG type of GBCA, which has a higher recurrence rate compared with the IG type. However, further large-scale multi-center studies are required to validate these findings.</p>\",\"PeriodicalId\":14691,\"journal\":{\"name\":\"Japanese Journal of Radiology\",\"volume\":\" \",\"pages\":\"1323-1334\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287180/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Japanese Journal of Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11604-025-01768-8\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese Journal of Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11604-025-01768-8","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/19 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的:本研究旨在评估细胞外体积(ECV)分数预测晚期胆囊癌(GBCA)壁侵犯模式的效用。材料和方法:回顾性评价在单一机构手术切除GBCA的患者。所有患者术前均行计算机断层扫描(CT)。根据病理检查,将GBCA的壁侵型分为浸润性生长(IG, n = 19)和破坏性生长(DG, n = 11)两组。通过输入患者的红细胞压积值和使用预对比和平衡相位图像的减法算法生成ECV图。2名放射科医师评估CT参数(Rad1和Rad2)。采用Mann-Whitney U检验来鉴别两组之间的重要CT参数。采用受试者工作特征(ROC)曲线分析测定诊断能力。采用Kaplan-Meier法估计无复发生存期(RFS),采用log-rank检验比较两组间的差异。结果:30例患者,平均年龄75.5岁;20名男性)接受评估。dg型平均ECV分数(Rad1, 34.5%;Rad2, 34.1%)显著高于ig型(Rad1, 28.5%;结论:ECV分数作为GBCA DG型最有价值的预测指标,其复发率高于IG型。然而,需要进一步的大规模多中心研究来验证这些发现。
Prediction of the wall-invasion pattern of advanced gallbladder carcinoma using extracellular volume fraction.
Purpose: This study aimed to evaluate the utility of extracellular volume (ECV) fraction for predicting wall-invasion patterns in advanced gallbladder carcinoma (GBCA).
Materials and methods: Patients who had surgically resected GBCA at a single institution were retrospectively evaluated. All patients underwent computed tomography (CT) before the surgery. Based on pathological examinations, the wall-invasion pattern of GBCA was classified into two groups: infiltrative growth (IG, n = 19) and destructive growth (DG, n = 11). ECV map was generated by inputting the patients' hematocrit values and subtraction algorithms using pre-contrast and equilibrium phase images. CT parameters were evaluated by two radiologists (Rad1 and Rad2). The Mann-Whitney U test was performed to identify significant CT parameters for differentiating between the two groups. The diagnostic ability was measured using receiver operating characteristic (ROC) curve analysis. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method, and differences between the two groups were compared using the log-rank test.
Results: Thirty patients (mean age, 75.5 years; 20 men) were evaluated. Mean ECV fraction of the DG-type (Rad1, 34.5%; Rad2, 34.1%) was significantly higher than that of the IG-type (Rad1, 28.5%; Rad2, 28.8%) (p < 0.05). The ECV values of the two radiologists indicated that the areas under the ROC curves for differentiation between the two groups were Rad1, 0.91 and Rad2, 0.84 (p < 0.05). Medium RFS of the DG-type (970 days) was significantly shorter than that of the IG-type (2200 days) (p < 0.05).
Conclusion: ECV fraction demonstrates potential as the most valuable predictor of the DG type of GBCA, which has a higher recurrence rate compared with the IG type. However, further large-scale multi-center studies are required to validate these findings.
期刊介绍:
Japanese Journal of Radiology is a peer-reviewed journal, officially published by the Japan Radiological Society. The main purpose of the journal is to provide a forum for the publication of papers documenting recent advances and new developments in the field of radiology in medicine and biology. The scope of Japanese Journal of Radiology encompasses but is not restricted to diagnostic radiology, interventional radiology, radiation oncology, nuclear medicine, radiation physics, and radiation biology. Additionally, the journal covers technical and industrial innovations. The journal welcomes original articles, technical notes, review articles, pictorial essays and letters to the editor. The journal also provides announcements from the boards and the committees of the society. Membership in the Japan Radiological Society is not a prerequisite for submission. Contributions are welcomed from all parts of the world.