呼吸道病毒和呼吸道纤毛之间的相互作用。

IF 9 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Review Pub Date : 2025-03-19 Print Date: 2025-01-01 DOI:10.1183/16000617.0224-2024

Katie Horton, Peter A C Wing, Claire L Jackson, Christopher J McCormick, Mary P Carroll, Jane S Lucas

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引用次数: 0

摘要

呼吸道上皮是吸入病原体的第一个接触点。上皮细胞在清除、感染和细菌定植中的作用是确定的。呼吸道病毒与纤毛的相互作用尚不清楚，但已知病毒以纤毛上皮细胞为目标进入、复制和传播。此外，一些呼吸道病毒损害和/或增强纤毛活动。本文综述了已知的纤毛与病毒感染之间的相互作用，以及呼吸道病毒如何影响纤毛功能并对人类健康产生后续影响。我们讨论了可用于研究呼吸道病毒与宿主气道之间关系的模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Interplay between respiratory viruses and cilia in the airways.

The airway epithelium is the first point of contact for inhaled pathogens. The role of epithelial cells in clearance, infection and colonisation of bacteria is established. The interactions of respiratory viruses and cilia is less understood, but viruses are known to target ciliated epithelial cells for entry, replication and dissemination. Furthermore, some respiratory viruses impair and/or enhance ciliary activity. This review examines what is known about the interactions between cilia and viral infection and how respiratory viruses effect cilia function with subsequent consequences for human health. We discuss the models which can be used to investigate the relationship between respiratory viruses and the host airway.

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来源期刊

European Respiratory Review Medicine-Pulmonary and Respiratory Medicine

CiteScore

14.40

自引率

1.30%

发文量

审稿时长

24 weeks

期刊介绍： The European Respiratory Review (ERR) is an open-access journal published by the European Respiratory Society (ERS), serving as a vital resource for respiratory professionals by delivering updates on medicine, science, and surgery in the field. ERR features state-of-the-art review articles, editorials, correspondence, and summaries of recent research findings and studies covering a wide range of topics including COPD, asthma, pulmonary hypertension, interstitial lung disease, lung cancer, tuberculosis, and pulmonary infections. Articles are published continuously and compiled into quarterly issues within a single annual volume.