小密度低密度脂蛋白作为老年人的生物标志物。

IF 2.5 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinical biochemistry Pub Date : 2025-03-17 DOI:10.1016/j.clinbiochem.2025.110916

Taina T. Katajamäki , Marja-Kaisa Koivula , Marika J. Salminen , Tero Vahlberg , Elisa T.M. Heikkilä , Anna M. Viljanen , Minna K. Löppönen , Raimo E. Isoaho , Sirkka-Liisa Kivelä , Matti Viitanen , Jorma Viikari , Laura Viikari , Kari J. Pulkki , Kerttu M. Irjala

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引用次数: 0

摘要

目的：小密度低密度脂蛋白（sdLDL）可致动脉粥样硬化性心血管疾病（ASCVD）。本研究的目的是在18 年的随访中对新发ASCVD患者的sdLDL-c进行前瞻性评估，并比较sdLDL-c与常规脂质和载脂蛋白与老年人ASCVD的关系。方法：本前瞻性研究共纳入1770名受试者 ≥ 64 岁，随访18年。sdLDL-c的测定采用均质选择性酶法。酶法测定总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-c）和甘油三酯（TG）水平。免疫浊度法分析载脂蛋白ApoA1和ApoB。使用Friedewald公式计算低密度脂蛋白胆固醇（LDL-c）水平。结果：根据Pearson相关系数，sdLDL-c浓度与LDL-c、非hdl -c、TC、ApoB浓度呈正相关。在随访期间，在未调整和调整的Cox回归模型中，64-76 岁男性的sdLDL-c与新发ASCVD显著相关。sdLDL-c校正风险比（95 % CI）为1.61（1.13-2.28）。在77-97 岁的男性、64-79岁或80-100 岁的女性中，sdLDL-c和ASCVD之间没有明显的关联。结论：老年人的脂质和载脂蛋白浓度高于推荐的目标值。此外，ASCVD组的脂质和载脂蛋白基线浓度并不高于对照组。我们的结果表明，sdLDL-c与ApoB一样好，比LDL-c更好。

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Small dense low-density lipoprotein as biomarker in the elderly

Objectives

Small dense low-density lipoprotein (sdLDL) is atherogenic and associated with atherosclerotic cardiovascular diseases (ASCVD). The aim of this study was to perform the prospective evaluation of sdLDL-c in new ASCVD over 18 years of follow up, and to compare the association of sdLDL-c and conventional lipids and apolipoproteins with ASCVD in the elderly.

Methods

This prospective study included a total of 1770 subjects ≥ 64 years of age with an 18-year follow-up period. The determination of sdLDL-c was measured by a homogenous, selective enzymatic method. Levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c) and triglycerides (TG) were determined by enzymatic methods. Apolipoproteins, ApoA1 and ApoB, were analyzed by immunonephelometric methods. Low-density lipoprotein cholesterol (LDL-c) levels were calculated using the Friedewald formula.

Results

According to Pearson’s correlation coefficients, sdLDL-c concentration was positively correlated with LDL-c, nonHDL-c, TC and ApoB concentrations. During follow up, sdLDL-c was significantly associated with new ASCVD in men aged 64–76 years in both unadjusted and adjusted Cox regression models. The adjusted hazard ratio (95 % CI) for sdLDL-c was 1.61 (1.13–2.28). No significant associations between sdLDL-c and ASCVD were observed in men aged 77–97 years, nor in women aged 64–79 or 80–100 years.

Conclusions

Lipid and apolipoprotein concentrations of the elderly were high compared to the recommended target values. In addition, lipid and apolipoprotein baseline concentrations were not higher in the ASCVD group than in the control group. Our results indicated that sdLDL-c is as good a marker as ApoB and better than LDL-c.

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来源期刊

Clinical biochemistry 医学-医学实验技术

CiteScore

5.10

自引率

0.00%

发文量

151

审稿时长

25 days

期刊介绍： Clinical Biochemistry publishes articles relating to clinical chemistry, molecular biology and genetics, therapeutic drug monitoring and toxicology, laboratory immunology and laboratory medicine in general, with the focus on analytical and clinical investigation of laboratory tests in humans used for diagnosis, prognosis, treatment and therapy, and monitoring of disease.