脆性X智力迟钝综合征相关蛋白1 (FXR1)在乳腺癌中的预后意义

IF 1.5 4区 医学 Q4 ONCOLOGY
Translational cancer research Pub Date : 2025-02-28 Epub Date: 2025-02-26 DOI:10.21037/tcr-24-1542
Ohud A Alsalmi, Abrar I Aljohani, Afaf A Alharthi, Amal F Gharib, Abdulrahman R Alrubayee, Ramy M Abbas, Meshari A Alsuwat, Khalid J Alzahrani, Batool S Alsaleh
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引用次数: 0

摘要

背景:乳腺癌(BC)是一种高度异质性的疾病,具有可变的组织学表现、生物学特征、临床结果和治疗反应。在过去17年中,沙特阿拉伯的BC病例数增加了两倍多,占妇女所有癌症病例的30%。因此,需要更大的努力来评估沙特阿拉伯BC的预后因素,以改善预后并提供更个性化的治疗。最近,脆性X智力迟钝综合征相关蛋白1 (FXR1)被确定为一种新的生物标志物,有助于肿瘤的发生;然而,其在BC中的作用尚未得到很好的研究。本研究旨在评估FXR1在原发性BC女性中的临床病理意义。方法:采用免疫组织化学方法测定100例BC组织标本中FXR1蛋白水平。我们评估了FXR1水平与临床病理参数和预后之间的关系,并通过评估BC基因表达Miner数据库(版本5)中公开可用的队列中的FXR1 mRNA水平验证了显著相关性。结果:FXR1高蛋白水平与肿瘤侵袭性显著相关,包括IIB和IIIC期、激素受体阴性、三阴性BC (TNBC)亚型和不良预后。与蛋白结果一致,高mRNA水平的FXR1与激素受体阴性和TNBC亚型显著相关。结论:本研究显示FXR1是女性BC患者预后不良的预后因素。需要进一步的功能研究来证实其在侵袭性BC中的作用及其作为治疗靶点的价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The prognostic significance of fragile X mental retardation syndrome-related protein 1 (FXR1) in breast cancer.

Background: Breast cancer (BC) is a highly heterogeneous disease with variable histological appearance, biological features, clinical outcomes, and treatment responses. The number of BC cases in Saudi Arabia has more than tripled during the last 17 years to constitute 30% of all cancer cases in women. Therefore, greater efforts are needed to evaluate prognostic factors for BC in Saudi Arabia to improve prognostication and provide more personalized therapy. Recently, fragile X mental retardation syndrome-related protein 1 (FXR1) was identified as a novel biomarker that contributes to oncogenesis; however, its role in BC has not been well studied. This study aims to evaluate the clinicopathological significance of FXR1 in women with primary BC.

Methods: The protein levels of FXR1 in BC tissue samples (n=100) were determined immunohistochemically. The associations between FXR1 levels and clinicopathological parameters and outcomes were evaluated, and significant associations were validated by assessing FXR1 mRNA levels in publicly available cohorts in the BC Gene-Expression Miner database (version 5).

Results: High protein levels of FXR1 were significantly associated with tumor aggressiveness, including stage IIB and IIIC and hormone receptor negativity, the triple-negative BC (TNBC) subtype, and poor outcomes. Consistent with the protein results, high mRNA levels of FXR1 were significantly associated with hormone receptor negativity and the TNBC subtype.

Conclusions: This study revealed that FXR1 is a prognostic factor for poor prognosis in women with BC. Further functional studies are needed to confirm its role in aggressive BC and its value as a therapeutic target.

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来源期刊
CiteScore
2.10
自引率
0.00%
发文量
252
期刊介绍: Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.
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