动脉自旋标记脑灌注成像预测小儿局灶性病变癫痫术后癫痫发作自由:一项初步研究。

IF 6.6 1区 医学 Q1 CLINICAL NEUROLOGY
Epilepsia Pub Date : 2025-03-18 DOI:10.1111/epi.18375
Antonio Giulio Gennari, Luca Gaito, Dorottya Cserpan, Raimund Kottke, Niklaus Krayenbühl, Andrea Rüegger, Ruth O' Gorman Tuura, Georgia Ramantani
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引用次数: 0

摘要

目的:本研究旨在确定将动脉自旋标记(ASL)灌注成像纳入术前计划是否能改善伴有局灶性皮质发育不良(FCD)或低级别癫痫相关肿瘤(LEATs)的耐药局灶性病变性癫痫患儿的术后癫痫发作结果。方法:我们回顾性分析了18名儿童(中位年龄= 4.8岁,四分位数间距= 1.9-11.5)的磁共振成像(MRI)扫描结果,这些儿童因FCD或leat相关的耐药癫痫切除,随访至少1年。所有患者术前均行ASL成像,术前和术后均行结构MRI检查。图像后处理,包括分割和共配准,评估解剖病变切除的完整性和asl衍生的灌注变化。DICE相似度评分测量了手术前和手术后分割的对齐,残差比评估了手术前分割在手术后剩余的百分比。这些指标随后与术后癫痫发作结果相关。结果:14例(78%)患者癫痫发作解除,13例(72%)病变完全切除。定性分析显示,完全切除腔内灌注改变与癫痫发作自由显著相关(p = 0.009),而完全切除解剖病变与癫痫发作自由无显著相关性(p = 0.57)。定量分析表明,通过DICE评分测量的灌注变化与切除腔的高度对齐与癫痫发作自由显著相关(p = 0.043),而病变与切除之间的对齐则无统计学意义(p = 0.44)。较大的残余灌注量与癫痫复发显著相关(p = 0.008)。意义:将ASL灌注显像纳入术前评估可以更好地描绘癫痫区,可能改善术后癫痫发作结果。这些发现支持ASL作为一个有价值的补充工具,在手术计划的药物抵抗儿童局灶性病变癫痫。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Brain perfusion imaging by arterial spin labeling predicts postsurgical seizure freedom in pediatric focal lesional epilepsy: A pilot study.

Objective: This study was undertaken to determine whether integrating arterial spin labeling (ASL) perfusion imaging into presurgical planning improves postsurgical seizure outcomes in children with pharmacoresistant focal lesional epilepsy associated with focal cortical dysplasia (FCD) or low-grade epilepsy-associated tumors (LEATs).

Methods: We retrospectively analyzed magnetic resonance imaging (MRI) scans from 18 children (median age = 4.8 years, interquartile range = 1.9-11.5) who underwent resection for FCD- or LEAT-associated pharmacoresistant epilepsy, with at least 1 year of follow-up. All patients underwent presurgical ASL imaging along with pre- and postsurgical structural MRI. Image postprocessing, including segmentation and coregistration, assessed the completeness of resection of the anatomical lesion and ASL-derived perfusion changes. DICE similarity scores measured the alignment of pre- to postsurgical segmentations, and the residue ratio assessed the percentage of presurgical segmentation remaining postresection. These metrics were then correlated with postsurgical seizure outcomes.

Results: Fourteen (78%) patients achieved seizure freedom, and 13 (72%) had complete lesion resection. Qualitative analysis showed that complete inclusion of the perfusion changes within the resection cavity significantly correlated with seizure freedom (p = .009), whereas complete resection of the anatomical lesion did not (p = .57). Quantitative analysis indicated that higher alignment of the perfusion changes with the resection cavity, measured by the DICE score, was significantly associated with seizure freedom (p = .043), whereas alignment between lesion and resection was not (p = .44). Larger residual perfusion volumes significantly correlated with seizure recurrence (p = .008).

Significance: Incorporating ASL perfusion imaging into presurgical evaluation may better delineate the epileptogenic zone, potentially improving postsurgical seizure outcomes. These findings support ASL as a valuable complementary tool in surgical planning for pharmacoresistant pediatric focal lesional epilepsy.

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来源期刊
Epilepsia
Epilepsia 医学-临床神经学
CiteScore
10.90
自引率
10.70%
发文量
319
审稿时长
2-4 weeks
期刊介绍: Epilepsia is the leading, authoritative source for innovative clinical and basic science research for all aspects of epilepsy and seizures. In addition, Epilepsia publishes critical reviews, opinion pieces, and guidelines that foster understanding and aim to improve the diagnosis and treatment of people with seizures and epilepsy.
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