黑人和白人之间炎症的差异：一项系统回顾和荟萃分析。

IF 8.8 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2025-03-16 DOI:10.1016/j.bbi.2025.03.019

Cameron R. Wiley , DeWayne P. Williams , Christine Sigrist , Briana N. Brownlow , Anna Markser , Suzi Hong , Esther M. Sternberg , Gaston Kapuku , Julian Koenig , Julian F. Thayer

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引用次数: 0

摘要

重要性：尽管黑人和白人之间持续存在健康差异，但炎症的种族差异尚未得到全面研究。目的：确定黑人和白人之间的循环炎症标志物水平是否存在显著差异。数据来源：通过系统检索四个电子数据库，于2022年1月确定了研究。通过参考文献列表和电子邮件联系确定了其他研究。研究选择：符合条件的研究包括由黑人和白人组成的全文实证文章，并报告了每个种族群体的炎症标志物的统计数据。在1368项可能符合条件的研究中，84项（6.6 %）代表100多万参与者符合研究选择标准。数据提取和综合：通过考虑相关协变量的meta回归评估偏倚风险。采用Cochrane q统计量和标准I2指数对数据异质性进行检验。随机效应模型用于计算标准化平均差异的效应大小估计值。主要观察指标：观察指标包括12种炎症标志物，包括c反应蛋白（CRP）、纤维蛋白原、白细胞介素-6 （IL-6）、肿瘤坏死因子-α (TNF-α)、可溶性细胞间粘附分子1 （sICAM-1）。结果：几种标记物具有可靠的样本量分析，包括CRP (White N = 934,594；黑色N = 55,234)，纤维蛋白原(白色N = 80,880；黑N = 18001)和IL-6(白N = 20269；黑色N = 14675)。初步结果显示CRP显著影响(k = 56,汇集树篱的g = 0.24),il - 6 (k = 33 g = 0.15),和纤维蛋白原(g k = 19日= 0.49),黑色的个体表现出更高的水平。结果还表明，sICAM-1 （k = 6,g = -0.46）和白细胞介素-10 （k = 4,g = -0.18）的水平显著影响白人。敏感性分析证实了对CRP、IL-6、纤维蛋白原和sICAM-1的强大作用，同时也揭示了对TNF-α （k = 18,g = -0.17）和白细胞介素-8 （k = 5,g = -0.19）的显著作用，白人个体显示出更高的水平。结论和相关性：目前的荟萃分析结果为常见循环炎症标志物的显著种族差异提供了证据，并说明了黑人和白人个体之间炎症谱差异的复杂性。审查预注册：普洛斯彼罗标识符- CRD42022312352。

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Differences in inflammation among black and white individuals: A systematic review and meta-analysis

Importance

Despite persisting health disparities between Black and White individuals, racial differences in inflammation have yet to be comprehensively examined.

Objective

To determine if significant differences in circulating levels of inflammatory markers between Black and White populations exist.

Data sources

Studies were identified through systematic searches of four electronic databases in January 2022. Additional studies were identified via reference lists and e-mail contact.

Study selection

Eligible studies included full-text empirical articles that consisted of Black and White individuals and reported statistics for inflammatory markers for each racial group. Of the 1368 potentially eligible studies, 84 (6.6 %) representing more than one million participants met study selection criteria.

Data extraction and synthesis

Risk of bias was assessed via meta regressions that considered relevant covariates. Data heterogeneity was tested using both the Cochrane Q-statistic and the standard I² index. Random effects models were used to calculate estimates of effect size from standardized mean differences.

Main outcomes and measures

Outcome measures included 12 inflammatory markers, including C-reactive protein (CRP), Fibrinogen, Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-α), and soluble intercellular adhesion molecule 1 (sICAM-1).

Results

Several markers had robust sample sizes for analysis, including CRP (White N = 934,594; Black N = 55,234), Fibrinogen (White N = 80,880; Black N = 18,001), and IL-6 (White N = 20,269; Black N = 14,675). Initial results indicated significant effects on CRP (k = 56, pooled Hedges’ g = 0.24), IL-6 (k = 33, g = 0.15), and Fibrinogen (k = 19, g = 0.49), with Black individuals showing higher levels. Results also indicated significant effects on sICAM-1 (k = 6, g = −0.46), and Interleukin-10 (k = 4, g = −0.18), with White individuals showing higher levels. Sensitivity analyses confirmed robust effects for CRP, IL-6, Fibrinogen, and sICAM-1 while also revealing significant effects on TNF-α (k = 18, g = −0.17) and Interleukin-8 (k = 5, g = −0.19), with White individuals showing higher levels of both.

Conclusions and relevance

Current meta-analytic results provide evidence for marked racial differences in common circulating inflammatory markers and illustrate the complexity of the inflammatory profile differences between Black and White individuals.

Review Pre-Registration: PROSPERO Identifier – CRD42022312352.

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.