纠正:解读肿瘤微环境:CXCL9和SPP1是肿瘤相关巨噬细胞极性和预后指标的关键决定因素

IF 27.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Xinming Su, Chenhao Liang, Ruixiu Chen, Shiwei Duan
{"title":"纠正:解读肿瘤微环境:CXCL9和SPP1是肿瘤相关巨噬细胞极性和预后指标的关键决定因素","authors":"Xinming Su, Chenhao Liang, Ruixiu Chen, Shiwei Duan","doi":"10.1186/s12943-025-02301-1","DOIUrl":null,"url":null,"abstract":"<p><b>Correction: Mol Cancer 23</b>,<b> 13 (2024)</b></p><p><b>https://doi.org/10.1186/s12943-023-01931-7</b></p><p>Following the publication of the original article [1], the authors realized that they used incorrect word when describing Fig. 1 in its caption, as follows: “A low CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis. “. To rectify this error, they have prepared the correct versions as follows: “A high CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis.”. The incorrect and correct Fig. 1 caption are provided below.</p><p> Incorrect Fig. 1 caption:</p><p> CXCL9:SPP1 polarity as an indicator of TME immune activity and prognosis in cancer patients. The CXCL9:SPP1 polarity could serve as an indicator of immune activity within the TME and may hold significance for patient prognosis. A low CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis. Conversely, a low CXCL9:SPP1 ratio characterizing TAM polarity indicates the prevalence of immunosuppressive and tumor-promoting factors within the TME, correlating with a poorer prognosis. CXCL9:SPP1, CXCL9 and SPP1; TAMs, tumor-associated macrophages; TME, tumor microenvironment.</p><p> Correct Fig. 1 caption:</p><p> CXCL9:SPP1 polarity as an indicator of TME immune activity and prognosis in cancer patients. The CXCL9:SPP1 polarity could serve as an indicator of immune activity within the TME and may hold significance for patient prognosis. A high CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis. Conversely, a low CXCL9:SPP1 ratio characterizing TAM polarity indicates the prevalence of immunosuppressive and tumor-promoting factors within the TME, correlating with a poorer prognosis. CXCL9:SPP1, CXCL9 and SPP1; TAMs, tumor-associated macrophages; TME, tumor microenvironment.</p><ol data-track-component=\"outbound reference\" data-track-context=\"references section\"><li data-counter=\"1.\"><p>Su X, Liang C, Chen R, et al. Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage Polarity and prognostic indicators. Mol Cancer. 2024;23:13. https://doi.org/10.1186/s12943-023-01931-7.</p><p>Article CAS PubMed PubMed Central Google Scholar </p></li></ol><p>Download references<svg aria-hidden=\"true\" focusable=\"false\" height=\"16\" role=\"img\" width=\"16\"><use xlink:href=\"#icon-eds-i-download-medium\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"></use></svg></p><h3>Authors and Affiliations</h3><ol><li><p>Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China</p><p>Xinming Su, Chenhao Liang, Ruixiu Chen &amp; Shiwei Duan</p></li><li><p>Department of Clinical Medicine, Hangzhou City University, Hangzhou, Zhejiang, China</p><p>Xinming Su, Chenhao Liang, Ruixiu Chen &amp; Shiwei Duan</p></li></ol><span>Authors</span><ol><li><span>Xinming Su</span>View author publications<p><span>You can also search for this author in</span><span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Chenhao Liang</span>View author publications<p><span>You can also search for this author in</span><span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Ruixiu Chen</span>View author publications<p><span>You can also search for this author in</span><span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Shiwei Duan</span>View author publications<p><span>You can also search for this author in</span><span>PubMed<span> </span>Google Scholar</span></p></li></ol><h3>Corresponding author</h3><p>Correspondence to Shiwei Duan.</p><h3>Publisher’s note</h3><p>Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p><p>The online version of the original article can be found at https://doi.org/10.1186/s12943-023-01931-7.</p><p><b>Open Access</b> This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.</p>\n<p>Reprints and permissions</p><img alt=\"Check for updates. 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0-.92-.08-1.33-.25-.41-.16-.77-.4-1.08-.7-.3-.31-.54-.69-.72-1.13-.17-.44-.26-.95-.26-1.52zm4.61-.62c0-.55-.11-.98-.34-1.28-.23-.31-.58-.47-1.06-.47-.41 0-.77.15-1.08.45-.31.29-.5.73-.57 1.3zm3.01 2.23c.31.24.61.43.92.57.3.13.63.2.98.2.38 0 .65-.08.83-.23s.27-.35.27-.6c0-.14-.05-.26-.13-.37-.08-.1-.2-.2-.34-.28-.14-.09-.29-.16-.47-.23l-.53-.22c-.23-.09-.46-.18-.69-.3-.23-.11-.44-.24-.62-.4s-.33-.35-.45-.55c-.12-.21-.18-.46-.18-.75 0-.61.23-1.1.68-1.49.44-.38 1.06-.57 1.83-.57.48 0 .91.08 1.29.25s.71.36.99.57l-.74.98c-.24-.17-.49-.32-.73-.42-.25-.11-.51-.16-.78-.16-.35 0-.6.07-.76.21-.17.15-.25.33-.25.54 0 .14.04.26.12.36s.18.18.31.26c.14.07.29.14.46.21l.54.19c.23.09.47.18.7.29s.44.24.64.4c.19.16.34.35.46.58.11.23.17.5.17.82 0 .3-.06.58-.17.83-.12.26-.29.48-.51.68-.23.19-.51.34-.84.45-.34.11-.72.17-1.15.17-.48 0-.95-.09-1.41-.27-.46-.19-.86-.41-1.2-.68z" fill="#535353"/></g></svg>\" width=\"57\"/><h3>Cite this article</h3><p>Su, X., Liang, C., Chen, R. <i>et al.</i> Correction: Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators. <i>Mol Cancer</i> <b>24</b>, 87 (2025). https://doi.org/10.1186/s12943-025-02301-1</p><p>Download citation<svg aria-hidden=\"true\" focusable=\"false\" height=\"16\" role=\"img\" width=\"16\"><use xlink:href=\"#icon-eds-i-download-medium\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"></use></svg></p><ul data-test=\"publication-history\"><li><p>Published<span>: </span><span><time datetime=\"2025-03-19\">19 March 2025</time></span></p></li><li><p>DOI</abbr><span>: </span><span>https://doi.org/10.1186/s12943-025-02301-1</span></p></li></ul><h3>Share this article</h3><p>Anyone you share the following link with will be able to read this content:</p><button data-track=\"click\" data-track-action=\"get shareable link\" data-track-external=\"\" data-track-label=\"button\" type=\"button\">Get shareable link</button><p>Sorry, a shareable link is not currently available for this article.</p><p data-track=\"click\" data-track-action=\"select share url\" data-track-label=\"button\"></p><button data-track=\"click\" data-track-action=\"copy share url\" data-track-external=\"\" data-track-label=\"button\" type=\"button\">Copy to clipboard</button><p> Provided by the Springer Nature SharedIt content-sharing initiative </p>","PeriodicalId":19000,"journal":{"name":"Molecular Cancer","volume":"9 1","pages":""},"PeriodicalIF":27.7000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correction: Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators\",\"authors\":\"Xinming Su, Chenhao Liang, Ruixiu Chen, Shiwei Duan\",\"doi\":\"10.1186/s12943-025-02301-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Correction: Mol Cancer 23</b>,<b> 13 (2024)</b></p><p><b>https://doi.org/10.1186/s12943-023-01931-7</b></p><p>Following the publication of the original article [1], the authors realized that they used incorrect word when describing Fig. 1 in its caption, as follows: “A low CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis. “. To rectify this error, they have prepared the correct versions as follows: “A high CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis.”. The incorrect and correct Fig. 1 caption are provided below.</p><p> Incorrect Fig. 1 caption:</p><p> CXCL9:SPP1 polarity as an indicator of TME immune activity and prognosis in cancer patients. The CXCL9:SPP1 polarity could serve as an indicator of immune activity within the TME and may hold significance for patient prognosis. A low CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis. Conversely, a low CXCL9:SPP1 ratio characterizing TAM polarity indicates the prevalence of immunosuppressive and tumor-promoting factors within the TME, correlating with a poorer prognosis. CXCL9:SPP1, CXCL9 and SPP1; TAMs, tumor-associated macrophages; TME, tumor microenvironment.</p><p> Correct Fig. 1 caption:</p><p> CXCL9:SPP1 polarity as an indicator of TME immune activity and prognosis in cancer patients. The CXCL9:SPP1 polarity could serve as an indicator of immune activity within the TME and may hold significance for patient prognosis. A high CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis. Conversely, a low CXCL9:SPP1 ratio characterizing TAM polarity indicates the prevalence of immunosuppressive and tumor-promoting factors within the TME, correlating with a poorer prognosis. CXCL9:SPP1, CXCL9 and SPP1; TAMs, tumor-associated macrophages; TME, tumor microenvironment.</p><ol data-track-component=\\\"outbound reference\\\" data-track-context=\\\"references section\\\"><li data-counter=\\\"1.\\\"><p>Su X, Liang C, Chen R, et al. Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage Polarity and prognostic indicators. Mol Cancer. 2024;23:13. https://doi.org/10.1186/s12943-023-01931-7.</p><p>Article CAS PubMed PubMed Central Google Scholar </p></li></ol><p>Download references<svg aria-hidden=\\\"true\\\" focusable=\\\"false\\\" height=\\\"16\\\" role=\\\"img\\\" width=\\\"16\\\"><use xlink:href=\\\"#icon-eds-i-download-medium\\\" xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\"></use></svg></p><h3>Authors and Affiliations</h3><ol><li><p>Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China</p><p>Xinming Su, Chenhao Liang, Ruixiu Chen &amp; Shiwei Duan</p></li><li><p>Department of Clinical Medicine, Hangzhou City University, Hangzhou, Zhejiang, China</p><p>Xinming Su, Chenhao Liang, Ruixiu Chen &amp; Shiwei Duan</p></li></ol><span>Authors</span><ol><li><span>Xinming Su</span>View author publications<p><span>You can also search for this author in</span><span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Chenhao Liang</span>View author publications<p><span>You can also search for this author in</span><span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Ruixiu Chen</span>View author publications<p><span>You can also search for this author in</span><span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Shiwei Duan</span>View author publications<p><span>You can also search for this author in</span><span>PubMed<span> </span>Google Scholar</span></p></li></ol><h3>Corresponding author</h3><p>Correspondence to Shiwei Duan.</p><h3>Publisher’s note</h3><p>Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p><p>The online version of the original article can be found at https://doi.org/10.1186/s12943-023-01931-7.</p><p><b>Open Access</b> This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. 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Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators. <i>Mol Cancer</i> <b>24</b>, 87 (2025). https://doi.org/10.1186/s12943-025-02301-1</p><p>Download citation<svg aria-hidden=\\\"true\\\" focusable=\\\"false\\\" height=\\\"16\\\" role=\\\"img\\\" width=\\\"16\\\"><use xlink:href=\\\"#icon-eds-i-download-medium\\\" xmlns:xlink=\\\"http://www.w3.org/1999/xlink\\\"></use></svg></p><ul data-test=\\\"publication-history\\\"><li><p>Published<span>: </span><span><time datetime=\\\"2025-03-19\\\">19 March 2025</time></span></p></li><li><p>DOI</abbr><span>: </span><span>https://doi.org/10.1186/s12943-025-02301-1</span></p></li></ul><h3>Share this article</h3><p>Anyone you share the following link with will be able to read this content:</p><button data-track=\\\"click\\\" data-track-action=\\\"get shareable link\\\" data-track-external=\\\"\\\" data-track-label=\\\"button\\\" type=\\\"button\\\">Get 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摘要

更正:Mol Cancer 23,13 (2024)https://doi.org/10.1186/s12943-023-01931-7Following在原始文章[1]发表后,作者意识到他们在描述图1的标题中使用了错误的单词,如下:“低CXCL9:SPP1比率定义TAM极性,表明TME富含免疫激活和抗肿瘤因子,预示着有希望的预后。”。为了纠正这一错误,他们准备了以下正确的版本:“高CXCL9:SPP1比率定义TAM极性,表明TME富含免疫激活和抗肿瘤因子,预示着有希望的预后。”错误和正确的图1标题如下所示。图1说明:CXCL9:SPP1极性作为癌症患者TME免疫活性和预后的指标。CXCL9:SPP1极性可作为TME内免疫活性的指标,可能对患者预后有重要意义。低CXCL9:SPP1比值决定TAM极性,提示TME富含免疫激活和抗肿瘤因子,预示预后良好。相反,表征TAM极性的低CXCL9:SPP1比值表明TME中存在免疫抑制和肿瘤促进因子,与较差的预后相关。CXCL9:SPP1、CXCL9、SPP1;tam,肿瘤相关巨噬细胞;TME,肿瘤微环境。正确图1标题:CXCL9:SPP1极性作为癌症患者TME免疫活性和预后的指标。CXCL9:SPP1极性可作为TME内免疫活性的指标,可能对患者预后有重要意义。高CXCL9:SPP1比值决定TAM极性,提示TME富含免疫激活和抗肿瘤因子,预示着良好的预后。相反,表征TAM极性的低CXCL9:SPP1比值表明TME中存在免疫抑制和肿瘤促进因子,与较差的预后相关。CXCL9:SPP1、CXCL9、SPP1;tam,肿瘤相关巨噬细胞;TME,肿瘤微环境。苏旭,梁超,陈锐,等。解读肿瘤微环境:CXCL9和SPP1是肿瘤相关巨噬细胞极性和预后指标的关键决定因素。巨蟹座。2024;23:13。https://doi.org/10.1186/s12943-023-01931-7.Article CAS PubMed PubMed Central b谷歌学者下载参考文献作者与单位杭州城市学院医学院浙江省神经修复新靶点与药物研究重点实验室,浙江杭州苏新明,梁晨豪,陈瑞秀等;杭州城市学院临床医学系,苏星明,梁晨豪,陈瑞秀等;端世伟作者苏新明查看作者出版物您也可以在pubmed b谷歌ScholarChenhao liang查看作者出版物您也可以在pubmed谷歌ScholarRuixiu陈瑞秀查看作者出版物您也可以在pubmed谷歌ScholarShiwei端世伟查看作者出版物您也可以在pubmed谷歌ScholarCorresponding author与端世伟通信。出版方声明:对于已出版地图的管辖权要求和机构关系,普林格·自然保持中立。本文遵循知识共享署名-非商业-非衍生品4.0国际许可协议,该协议允许以任何媒介或格式进行非商业用途、共享、分发和复制,只要您适当地注明原作者和来源,并提供知识共享许可协议的链接。并注明你是否修改了授权材料。根据本许可协议,您无权分享源自本文或其部分内容的改编材料。本文中的图像或其他第三方材料包含在文章的知识共享许可协议中,除非在材料的署名中另有说明。如果材料未包含在文章的知识共享许可中,并且您的预期用途不被法律法规允许或超过允许的用途,您将需要直接获得版权所有者的许可。要查看本许可协议的副本,请访问http://creativecommons.org/licenses/by-nc-nd/4.0/.Reprints和permission.com。纠正:解读肿瘤微环境:CXCL9和SPP1是肿瘤相关巨噬细胞极性和预后指标的关键决定因素。癌症学报,24,87(2025)。https://doi.org/10.1186/s12943-025-02301-1Download引文出版日期:2025年3月19日doi: https://doi.org/10。 分享这篇文章,任何你分享了以下链接的人都可以阅读这篇文章:获得可共享的链接对不起,本文目前没有可共享的链接。复制到剪贴板由施普林格自然共享内容倡议提供
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Correction: Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators

Correction: Mol Cancer 23, 13 (2024)

https://doi.org/10.1186/s12943-023-01931-7

Following the publication of the original article [1], the authors realized that they used incorrect word when describing Fig. 1 in its caption, as follows: “A low CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis. “. To rectify this error, they have prepared the correct versions as follows: “A high CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis.”. The incorrect and correct Fig. 1 caption are provided below.

Incorrect Fig. 1 caption:

CXCL9:SPP1 polarity as an indicator of TME immune activity and prognosis in cancer patients. The CXCL9:SPP1 polarity could serve as an indicator of immune activity within the TME and may hold significance for patient prognosis. A low CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis. Conversely, a low CXCL9:SPP1 ratio characterizing TAM polarity indicates the prevalence of immunosuppressive and tumor-promoting factors within the TME, correlating with a poorer prognosis. CXCL9:SPP1, CXCL9 and SPP1; TAMs, tumor-associated macrophages; TME, tumor microenvironment.

Correct Fig. 1 caption:

CXCL9:SPP1 polarity as an indicator of TME immune activity and prognosis in cancer patients. The CXCL9:SPP1 polarity could serve as an indicator of immune activity within the TME and may hold significance for patient prognosis. A high CXCL9:SPP1 ratio defining TAM polarity suggests a TME enriched with immune activation and anti-tumor factors, pointing towards a promising prognosis. Conversely, a low CXCL9:SPP1 ratio characterizing TAM polarity indicates the prevalence of immunosuppressive and tumor-promoting factors within the TME, correlating with a poorer prognosis. CXCL9:SPP1, CXCL9 and SPP1; TAMs, tumor-associated macrophages; TME, tumor microenvironment.

  1. Su X, Liang C, Chen R, et al. Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage Polarity and prognostic indicators. Mol Cancer. 2024;23:13. https://doi.org/10.1186/s12943-023-01931-7.

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Authors and Affiliations

  1. Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang, China

    Xinming Su, Chenhao Liang, Ruixiu Chen & Shiwei Duan

  2. Department of Clinical Medicine, Hangzhou City University, Hangzhou, Zhejiang, China

    Xinming Su, Chenhao Liang, Ruixiu Chen & Shiwei Duan

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  1. Xinming SuView author publications

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  2. Chenhao LiangView author publications

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  3. Ruixiu ChenView author publications

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  4. Shiwei DuanView author publications

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Correspondence to Shiwei Duan.

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Su, X., Liang, C., Chen, R. et al. Correction: Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators. Mol Cancer 24, 87 (2025). https://doi.org/10.1186/s12943-025-02301-1

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来源期刊
Molecular Cancer
Molecular Cancer 医学-生化与分子生物学
CiteScore
54.90
自引率
2.70%
发文量
224
审稿时长
2 months
期刊介绍: Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.
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