Senescence-associated secretory phenotype regulation by dual-drug delivery biomimetic nanoplatform for enhanced tumor chemotherapy.

Wang and colleagues provide a comprehensive evaluation of a biomimetic platform in which a specially designed drug delivery system, referred to in the manuscript as mPtP@Lipo, is used to increased penetration of dense stromatous tumors. This work represents a significant advancement in the treatment of desmoplastic tumors by targeting the tumor microenvironment (TME), particularly focusing on remodeling cancer-associated fibroblasts (CAFs). The study leverages previous work, which has demonstrated that platinum (Pt)-based chemotherapeutic regimens can induce a senescence-associated secretory phenotype (SASP) through persistent DNA damage, which can contribute to an immunosuppressive tumor immune microenvironment.