巴基斯坦家族性高胆固醇血症的患病率：150万人的汇总分析以及与该地区其他国家的比较

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Global Heart Pub Date : 2025-03-10 eCollection Date: 2025-01-01 DOI:10.5334/gh.1413

Madeeha Khan, Quratul Ain, Jaka Sikonja, Hijab Batool, Muhammad Qasim Hayat, Mohammad Iqbal Khan, Urh Groselj, Fouzia Sadiq

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引用次数: 0

摘要

背景：家族性高胆固醇血症（FH）是一种遗传性疾病，可引起LDL-C水平升高，导致过早心血管疾病，但仍未得到充分诊断。这项研究的目的是利用来自多个实验室网络的数据确定FH在巴基斯坦的流行情况，并将其与该地区其他国家进行比较。方法：该研究分析了来自巴基斯坦两个大型实验室网络的脂质谱数据，应用早期诊断预防早期死亡（MEDPED） LDL-C标准对普通人群进行FH病例识别。通过结合报告巴基斯坦流行率的研究数据，计算出巴基斯坦FH流行率的综合流行率估计。进行了系统审查，以评估南亚和东南亚国家的艾滋病毒流行情况。结果：分析545,087例（中位年龄45岁，58.2%男性），发现2,911例FH病例[0.55%，95%可信区间（CI）： 0.53-0.57%)，相当于1:182的患病率。与先前巴基斯坦的一项研究（共计1,533,393名受试者）进行汇总分析，估计巴基斯坦的FH总体流行率为1:273 （95% CI: 0.21-0.64%）。结论：本研究提供了巴基斯坦FH患病率的最新估计，并强调了南亚和东南亚数据的缺乏。

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Prevalence of Familial Hypercholesterolemia in Pakistan: A Pooled Analysis of 1.5 Million Individuals and Comparison with Other Countries of the Region.

Background: Familial hypercholesterolemia (FH) is an inherited disorder that causes elevated LDL-C levels leading to premature cardiovascular disease but remains underdiagnosed. This study aims to determine the prevalence of FH in Pakistan using data from multiple laboratory networks and compare it with other counties of the region.

Methods: The study analyzed lipid profile data from two large laboratory networks in Pakistan, applying Make Early Diagnosis to Prevent Early Death (MEDPED) LDL-C criteria for the general population to identify FH cases. A pooled prevalence estimate of prevalence of FH in Pakistan was calculated by combining the data of studies reporting prevalence in Pakistan. A systematic review was conducted to assess FH prevalence in South and Southeast Asian countries.

Results: Analysis of 545,087 individuals (Median age 45 years, 58.2% males) identified 2,911 FH cases [0.55%, 95% confidence interval (CI): 0.53-0.57%), equivalent to a prevalence of 1:182. Pooled analysis with a previous Pakistani study, totaling 1,533,393 subjects, estimated the overall FH prevalence in Pakistan at 1:273 (95% CI: 0.21-0.64%). Prevalence decreased with age, being highest in the <20 years group (1:29), while no gender differences were observed. A systematic review of South and Southeast Asian countries revealed limited data, with FH prevalence estimates missing for majority of the countries of the region.

Conclusion: This study provides an updated estimate of FH prevalence in Pakistan and highlights the scarcity of data in South and Southeast Asia.

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来源期刊

Global Heart Medicine-Cardiology and Cardiovascular Medicine

CiteScore

5.70

自引率

5.40%

发文量

审稿时长

5 weeks

期刊介绍： Global Heart offers a forum for dialogue and education on research, developments, trends, solutions and public health programs related to the prevention and control of cardiovascular diseases (CVDs) worldwide, with a special focus on low- and middle-income countries (LMICs). Manuscripts should address not only the extent or epidemiology of the problem, but also describe interventions to effectively control and prevent CVDs and the underlying factors. The emphasis should be on approaches applicable in settings with limited resources. Economic evaluations of successful interventions are particularly welcome. We will also consider negative findings if important. While reports of hospital or clinic-based treatments are not excluded, particularly if they have broad implications for cost-effective disease control or prevention, we give priority to papers addressing community-based activities. We encourage submissions on cardiovascular surveillance and health policies, professional education, ethical issues and technological innovations related to prevention. Global Heart is particularly interested in publishing data from updated national or regional demographic health surveys, World Health Organization or Global Burden of Disease data, large clinical disease databases or registries. Systematic reviews or meta-analyses on globally relevant topics are welcome. We will also consider clinical research that has special relevance to LMICs, e.g. using validated instruments to assess health-related quality-of-life in patients from LMICs, innovative diagnostic-therapeutic applications, real-world effectiveness clinical trials, research methods (innovative methodologic papers, with emphasis on low-cost research methods or novel application of methods in low resource settings), and papers pertaining to cardiovascular health promotion and policy (quantitative evaluation of health programs.