微管晶格上运动行走引起的微管蛋白移除和交换模型

IF 2 4区数学 Q2 BIOLOGY

Journal of Theoretical Biology Pub Date : 2025-03-15 DOI:10.1016/j.jtbi.2025.112088

Ping Xie

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引用次数: 0

摘要

马达在微管晶格上行走会引起gtp -微管蛋白的解体，产生缺陷，通过加入gtp -微管蛋白来修复缺陷。为了探究其潜在的机制，本文提出了一个模型。在此模型的基础上，从理论上研究了驱动马达诱导缺陷产生、缺陷修复和微管蛋白交换的动力学过程。理论结果很好地解释了现有的实验数据。并给出了预测结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A model of tubulin removal and exchange caused by kinesin motor walking on microtubule lattices

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A model of tubulin removal and exchange caused by kinesin motor walking on microtubule lattices

The kinesin motor walking on microtubule lattices can cause disassembly of GDP-tubulins, generating defects, and repair the defects by incorporating GTP-tubulins. To explore the underlying mechanism, a model is proposed here. On the basis of the model, the dynamics of the defect generation, defect repair and tubulin exchange induced by the kinesin motor is studied theoretically. The theoretical results explain well the available experimental data. Moreover, predicted results are provided.

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来源期刊

Journal of Theoretical Biology 生物-生物学

CiteScore

4.20

自引率

5.00%

发文量

218

审稿时长

51 days

期刊介绍： The Journal of Theoretical Biology is the leading forum for theoretical perspectives that give insight into biological processes. It covers a very wide range of topics and is of interest to biologists in many areas of research, including: • Brain and Neuroscience • Cancer Growth and Treatment • Cell Biology • Developmental Biology • Ecology • Evolution • Immunology, • Infectious and non-infectious Diseases, • Mathematical, Computational, Biophysical and Statistical Modeling • Microbiology, Molecular Biology, and Biochemistry • Networks and Complex Systems • Physiology • Pharmacodynamics • Animal Behavior and Game Theory Acceptable papers are those that bear significant importance on the biology per se being presented, and not on the mathematical analysis. Papers that include some data or experimental material bearing on theory will be considered, including those that contain comparative study, statistical data analysis, mathematical proof, computer simulations, experiments, field observations, or even philosophical arguments, which are all methods to support or reject theoretical ideas. However, there should be a concerted effort to make papers intelligible to biologists in the chosen field.