{"title":"可卡因引起的意外死亡:一个可能的原因。","authors":"A H Anton","doi":"10.1177/106002808802201123","DOIUrl":null,"url":null,"abstract":"CASE I An 18-year-old Hispanic man with drug-resistant pulmonary metastases of osteosarcoma received ifosfamide 1.6 g/m'/d iv for five days with mesna 400 mg/m' iv 15 minutes, 4 and 6 hours after each dose of ifosfamide. Treatment courses were given at threeto four-week intervals. After treatment with mesna on day I of his second course he developed generalized urticaria which required symptomatic treatment with dexamethasone and diphenhydramine. Continuation of ifosfamide/mesna over the remaining four days of treatment was not associated with recurrence of urticaria.","PeriodicalId":77709,"journal":{"name":"Drug intelligence & clinical pharmacy","volume":"22 11","pages":"914"},"PeriodicalIF":0.0000,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/106002808802201123","citationCount":"3","resultStr":"{\"title\":\"Unexpected cocaine-induced fatalities: a possible cause.\",\"authors\":\"A H Anton\",\"doi\":\"10.1177/106002808802201123\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"CASE I An 18-year-old Hispanic man with drug-resistant pulmonary metastases of osteosarcoma received ifosfamide 1.6 g/m'/d iv for five days with mesna 400 mg/m' iv 15 minutes, 4 and 6 hours after each dose of ifosfamide. Treatment courses were given at threeto four-week intervals. After treatment with mesna on day I of his second course he developed generalized urticaria which required symptomatic treatment with dexamethasone and diphenhydramine. Continuation of ifosfamide/mesna over the remaining four days of treatment was not associated with recurrence of urticaria.\",\"PeriodicalId\":77709,\"journal\":{\"name\":\"Drug intelligence & clinical pharmacy\",\"volume\":\"22 11\",\"pages\":\"914\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/106002808802201123\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug intelligence & clinical pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/106002808802201123\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug intelligence & clinical pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/106002808802201123","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Unexpected cocaine-induced fatalities: a possible cause.
CASE I An 18-year-old Hispanic man with drug-resistant pulmonary metastases of osteosarcoma received ifosfamide 1.6 g/m'/d iv for five days with mesna 400 mg/m' iv 15 minutes, 4 and 6 hours after each dose of ifosfamide. Treatment courses were given at threeto four-week intervals. After treatment with mesna on day I of his second course he developed generalized urticaria which required symptomatic treatment with dexamethasone and diphenhydramine. Continuation of ifosfamide/mesna over the remaining four days of treatment was not associated with recurrence of urticaria.
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