淋巴血管侵袭预测阴茎局部鳞状细胞癌的癌症特异性死亡率

IF 2.7 3区医学 Q3 ONCOLOGY

Clinical genitourinary cancer Pub Date : 2025-02-20 DOI:10.1016/j.clgc.2025.102320

Natali Rodriguez Peñaranda , Letizia Maria Ippolita Jannello , Francesco Di Bello , Carolin Siech , Mario de Angelis , Jordan A. Goyal , Zhe Tian , Fred Saad , Shahrokh F. Shariat , Nicola Longo , Felix K.H. Chun , Alberto Briganti , Ottavio de Cobelli , Stefano Di Bari , Stefano Puliatti , Salvatore Micali , Pierre I. Karakiewicz

{"title":"淋巴血管侵袭预测阴茎局部鳞状细胞癌的癌症特异性死亡率","authors":"Natali Rodriguez Peñaranda , Letizia Maria Ippolita Jannello , Francesco Di Bello , Carolin Siech , Mario de Angelis , Jordan A. Goyal , Zhe Tian , Fred Saad , Shahrokh F. Shariat , Nicola Longo , Felix K.H. Chun , Alberto Briganti , Ottavio de Cobelli , Stefano Di Bari , Stefano Puliatti , Salvatore Micali , Pierre I. Karakiewicz","doi":"10.1016/j.clgc.2025.102320","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Lymphovascular invasion (LVI) is a predictor of unfavorable stage at presentation in squamous cell carcinoma of the penis (SCCP). However, it is unknown if LVI may also predict cancer-specific mortality (CSM), especially in patients with localized SCCP in whom important differences in the treated natural history may exist. We addressed this knowledge gap in localized (T1b-T2N0M0) SCCP patients treated with penectomy.</div></div><div><h3>Methods</h3><div>Within the Surveillance, Epidemiology, and End Results database (SEER 2010-2021), we identified localized SCCP patients treated with penectomy in whom LVI status was available. Kaplan-Meier analyses and multivariable Cox regression models (CRM) addressed CSM. Covariates consisted of age at diagnosis, T stage, penectomy type, and race/ethnicity.</div></div><div><h3>Results</h3><div>Of 685 localized SCCP patients, 144 (21%) were LVI-positive. At three-years of follow-up CSM-free survival rates were 85% versus 69% in respectively LVI-negative versus LVI-positive patients (<em>P</em> < 0.001), which resulted in a univariable hazard ratio [HR] of 2.5 (<em>P</em> < 0.01). After multivariable adjustment in Cox regression models, LVI-positive status independently predicted a 2.6-fold higher CSM (<em>P</em> < 0.001). In subgroup analyses, LVI also independently predicted higher CSM in T1b (HR = 3.0; <em>P</em> = 0.01), as well as in T2 (HR= 2.5; <em>P</em> < 0.001) SCCP patients.</div></div><div><h3>Conclusion</h3><div>In localized SCCP patients, LVI is a highly significant independent predictor of higher CSM in both T1b and T2 stages and may warrant consideration for use in clinical practice.</div></div>","PeriodicalId":10380,"journal":{"name":"Clinical genitourinary cancer","volume":"23 3","pages":"Article 102320"},"PeriodicalIF":2.7000,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lymphovascular Invasion Predicts Cancer-specific Mortality in Penile Localized Squamous Cell Carcinoma\",\"authors\":\"Natali Rodriguez Peñaranda , Letizia Maria Ippolita Jannello , Francesco Di Bello , Carolin Siech , Mario de Angelis , Jordan A. Goyal , Zhe Tian , Fred Saad , Shahrokh F. Shariat , Nicola Longo , Felix K.H. Chun , Alberto Briganti , Ottavio de Cobelli , Stefano Di Bari , Stefano Puliatti , Salvatore Micali , Pierre I. Karakiewicz\",\"doi\":\"10.1016/j.clgc.2025.102320\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Lymphovascular invasion (LVI) is a predictor of unfavorable stage at presentation in squamous cell carcinoma of the penis (SCCP). However, it is unknown if LVI may also predict cancer-specific mortality (CSM), especially in patients with localized SCCP in whom important differences in the treated natural history may exist. We addressed this knowledge gap in localized (T1b-T2N0M0) SCCP patients treated with penectomy.</div></div><div><h3>Methods</h3><div>Within the Surveillance, Epidemiology, and End Results database (SEER 2010-2021), we identified localized SCCP patients treated with penectomy in whom LVI status was available. Kaplan-Meier analyses and multivariable Cox regression models (CRM) addressed CSM. Covariates consisted of age at diagnosis, T stage, penectomy type, and race/ethnicity.</div></div><div><h3>Results</h3><div>Of 685 localized SCCP patients, 144 (21%) were LVI-positive. At three-years of follow-up CSM-free survival rates were 85% versus 69% in respectively LVI-negative versus LVI-positive patients (<em>P</em> < 0.001), which resulted in a univariable hazard ratio [HR] of 2.5 (<em>P</em> < 0.01). After multivariable adjustment in Cox regression models, LVI-positive status independently predicted a 2.6-fold higher CSM (<em>P</em> < 0.001). In subgroup analyses, LVI also independently predicted higher CSM in T1b (HR = 3.0; <em>P</em> = 0.01), as well as in T2 (HR= 2.5; <em>P</em> < 0.001) SCCP patients.</div></div><div><h3>Conclusion</h3><div>In localized SCCP patients, LVI is a highly significant independent predictor of higher CSM in both T1b and T2 stages and may warrant consideration for use in clinical practice.</div></div>\",\"PeriodicalId\":10380,\"journal\":{\"name\":\"Clinical genitourinary cancer\",\"volume\":\"23 3\",\"pages\":\"Article 102320\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical genitourinary cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1558767325000217\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical genitourinary cancer","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1558767325000217","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

淋巴血管浸润（LVI）是阴茎鳞状细胞癌（SCCP）出现时不良分期的预测因子。然而，目前尚不清楚LVI是否也可以预测癌症特异性死亡率（CSM），特别是对于局部SCCP患者，其治疗自然史可能存在重要差异。我们在接受阴茎切除术的局部（T1b-T2N0M0） SCCP患者中解决了这一知识差距。方法在监测、流行病学和最终结果数据库（SEER 2010-2021）中，我们确定了接受阴茎切除术且LVI状态可用的局部SCCP患者。Kaplan-Meier分析和多变量Cox回归模型（CRM）解决了CSM问题。协变量包括诊断时的年龄、T期、阴茎切除术类型和种族。结果685例局部SCCP患者中，144例（21%）为lvi阳性。随访3年时，lvi阴性和lvi阳性患者无csm生存率分别为85%和69% (P <；0.001)，导致单变量风险比[HR]为2.5 (P <；0.01)。Cox回归模型多变量调整后，lvi阳性独立预测CSM升高2.6倍(P <；0.001)。在亚组分析中，LVI也独立预测了T1b患者较高的CSM (HR = 3.0；P = 0.01)和T2 (HR= 2.5；P & lt;0.001) SCCP患者。结论在局限性SCCP患者中，LVI是T1b和T2期CSM升高的高度显著的独立预测因子，可能值得考虑在临床实践中使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Lymphovascular Invasion Predicts Cancer-specific Mortality in Penile Localized Squamous Cell Carcinoma

Introduction

Lymphovascular invasion (LVI) is a predictor of unfavorable stage at presentation in squamous cell carcinoma of the penis (SCCP). However, it is unknown if LVI may also predict cancer-specific mortality (CSM), especially in patients with localized SCCP in whom important differences in the treated natural history may exist. We addressed this knowledge gap in localized (T1b-T2N0M0) SCCP patients treated with penectomy.

Methods

Within the Surveillance, Epidemiology, and End Results database (SEER 2010-2021), we identified localized SCCP patients treated with penectomy in whom LVI status was available. Kaplan-Meier analyses and multivariable Cox regression models (CRM) addressed CSM. Covariates consisted of age at diagnosis, T stage, penectomy type, and race/ethnicity.

Results

Of 685 localized SCCP patients, 144 (21%) were LVI-positive. At three-years of follow-up CSM-free survival rates were 85% versus 69% in respectively LVI-negative versus LVI-positive patients (P < 0.001), which resulted in a univariable hazard ratio [HR] of 2.5 (P < 0.01). After multivariable adjustment in Cox regression models, LVI-positive status independently predicted a 2.6-fold higher CSM (P < 0.001). In subgroup analyses, LVI also independently predicted higher CSM in T1b (HR = 3.0; P = 0.01), as well as in T2 (HR= 2.5; P < 0.001) SCCP patients.

Conclusion

In localized SCCP patients, LVI is a highly significant independent predictor of higher CSM in both T1b and T2 stages and may warrant consideration for use in clinical practice.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Clinical genitourinary cancer 医学-泌尿学与肾脏学

CiteScore

5.20

自引率

6.20%

发文量

201

审稿时长

54 days

期刊介绍： Clinical Genitourinary Cancer is a peer-reviewed journal that publishes original articles describing various aspects of clinical and translational research in genitourinary cancers. Clinical Genitourinary Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of genitourinary cancers. The main emphasis is on recent scientific developments in all areas related to genitourinary malignancies. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.