铑催化乙烯基苯并噁嗪酮的区域选择性脱羧氢硒化和氢硫化反应

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2025-03-03 DOI:10.1039/d4qo02084g

Yuan-Yi Lu , Guirong You , Yu Teng , Jun Zhao , Yi-Dong Zhong , Hong-Shuang Li

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引用次数: 0

摘要

研究了铑(I)催化多种乙烯基苯并恶嗪酮脱羧加氢反应。硒醇或其代物与底物的偶联使烯丙基硒化物具有良好的线性选择性和e选择性，而硫醇的转化使烯丙基硫化物具有显著的分支选择性。广泛的底物范围和令人满意的官能团耐受性使该方案成为涉及活性π-烯丙基金属的区域选择性加氢功能化的新范例。

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Rhodium-catalyzed regioselective decarboxylative hydroselenation and hydrothiolation of vinyl benzoxazinanones†

A rhodium(i)-catalyzed decarboxylative hydrochalcogenation of diverse vinyl benzoxazinanones is developed. The coupling of selenols or their surrogates with substrates provides allylic selenides with excellent linear- and E-selectivity, while the transformation of thiols delivers allylic sulfides with remarkable branch-selectivity. The broad substrate scope in combination with satisfactory functional group tolerance makes this protocol a new paradigm for regioselective hydrofunctionalization that involves reactive π-allylmetal species.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

发文量