Cesar Reategui Sanchez, Roberto Secchi Del Rio, Isabel Dos Santos Marques, Mary R Schwartz, Rachel Schiesser, Eric M Haas
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Low-Grade Cystic Mucinous Neoplasm of the Colon: A New Entity? Case Report and Review of Literature.
Low-grade cystic mucinous neoplasm of the sigmoid colon has never been previously reported and a classification for such a tumor does not currently exist. Here, we present a case of low-grade cystic mucinous neoplasm of the sigmoid colon and discuss the differential diagnosis especially as it relates to clinical management. Our case is a 68-year-old male who presented with anemia and a history of a lower gastrointestinal tract bleed. He denied abdominal pain and weight loss. A colonoscopy was done for further investigation, and he was found to have a 4-cm nonbleeding submucosal mass in the descending colon. Mucosal biopsies were inconclusive. An MRI of the abdomen and pelvis showed a 7.4 × 4.6 cm complex fluid collection involving the mid sigmoid colon with extensive diverticulosis and wall thickening of the sigmoid colon. The differential diagnosis included sequela of diverticulitis vs. neoplasm. Due to the increased risk of obstruction or perforation, a sigmoid resection was recommended. The patient underwent a robotic low anterior resection (LAR). Histological examination demonstrated a cystic mucinous neoplasm filled with acellular mucin and lined by pseudostratified columnar cells with low-grade dysplasia. The tumor involved the muscularis propria and subserosa. Cystic mucinous neoplasm of the colon is not currently recognized among tumors of the colon. Its malignant potential is uncertain. This is the first case report describing a cystic mucinous neoplasm of the sigmoid colon. Recognition of this unusual tumor can help to guide appropriate clinical management and guide further treatment.
期刊介绍：
The Journal of Gastrointestinal Cancer is a multidisciplinary medium for the publication of novel research pertaining to cancers arising from the gastrointestinal tract.The journal is dedicated to the most rapid publication possible.The journal publishes papers in all relevant fields, emphasizing those studies that are helpful in understanding and treating cancers affecting the esophagus, stomach, liver, gallbladder and biliary tree, pancreas, small bowel, large bowel, rectum, and anus. In addition, the Journal of Gastrointestinal Cancer publishes basic and translational scientific information from studies providing insight into the etiology and progression of cancers affecting these organs. New insights are provided from diverse areas of research such as studies exploring pre-neoplastic states, risk factors, epidemiology, genetics, preclinical therapeutics, surgery, radiation therapy, novel medical therapeutics, clinical trials, and outcome studies.In addition to reports of original clinical and experimental studies, the journal also publishes: case reports, state-of-the-art reviews on topics of immediate interest or importance; invited articles analyzing particular areas of pancreatic research and knowledge; perspectives in which critical evaluation and conflicting opinions about current topics may be expressed; meeting highlights that summarize important points presented at recent meetings; abstracts of symposia and conferences; book reviews; hypotheses; Letters to the Editors; and other items of special interest, including:Complex Cases in GI Oncology: This is a new initiative to provide a forum to review and discuss the history and management of complex and involved gastrointestinal oncology cases. The format will be similar to a teaching case conference where a case vignette is presented and is followed by a series of questions and discussion points. A brief reference list supporting the points made in discussion would be expected.
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