冥想作为辅助治疗在门诊功能性消化不良患者胃肠道生活质量中的作用:一项随机试验。

Q3 Medicine
Monika Pathania, Madhav Banjade, Meenakshi Khapre, Itish Patnaik, Divya Kanchibhotla, Minakshi Dhar
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引用次数: 0

摘要

背景:功能性消化不良(FD)是就诊最常见的原因之一。FD患者产生大量的直接和间接支出,并可能产生影响生活质量的重大经济负担。我们的研究旨在评估冥想作为诊断为FD的个体标准治疗的辅助治疗的有效性。这将为FD等疾病探索更具成本效益的治疗管理,FD被认为与肠脑轴有关。冥想是一种非药物治疗,更安全,更经济,它的辅助使用可以减少或避免长期使用质子泵抑制剂(PPI)和三环抗抑郁药(TCA)的不良反应。目的:我们希望全面评估冥想作为FD患者辅助治疗的作用,并将其与单独接受标准治疗的对照组进行比较。主要目的是胃肠道生活质量指数(GIQLI)评分的变化,次要目的是评估干预前后医院焦虑抑郁量表(HADS)评分和匹兹堡睡眠质量指数(PSQI)评分的变化。方法:将符合纳入标准的患者平均分为两组(实验组和对照组)。实验组给予消化不良的标准治疗(PPI、多潘立酮、TCAs)和Vaishvanara Agni冥想(VAM),对照组单独给予标准治疗。两组在第0、4和8周比较GIQLI评分、HADS (HADS- a和HADS评分)和PSQI评分的变化。结果:我们的研究显示,与基线时间点相比,两组患者在第4周和第8周的GIQLI、HADS-A、HADS-D和PSQI评分均发生了显著变化。然而,当两组直接比较时,观察到实验组在8周后的GIQLI评分、8周后的HADS-D评分、4周后的PSQI评分与对照组相比有显著差异。这些差异在统计学上是显著的。结论:FD没有确定的结构或生化原因,使其成为功能性胃肠道(GI)疾病,需要量身定制的治疗方法。我们的试点随机对照试验(RCT)调查了冥想作为FD辅助治疗的影响,揭示了与单独标准治疗相比,在胃肠道健康、心理健康和睡眠质量方面的改善。该研究建议将冥想纳入FD和类似疾病的管理中,强调其整体性,不仅解决特定症状,还解决整体健康问题。本研究率先将冥想作为FD的补充方法,在提高GIQLI、HADS和PSQI分数方面提供了有希望的结果,从而增加了已有文献的价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Meditation as Adjuvant Therapy on Gastrointestinal Quality of Life among Individuals with Functional Dyspepsia in an Outpatient Setting: A Randomized Pilot Trial.

Background: Functional dyspepsia (FD) is one of the most common reasons for medical visits. Patients with FD incur large direct and indirect expenditures and may have significant financial burdens that affect quality of life. Our study aimed to assess the effectiveness of meditation as an adjuvant to the standard treatment in individuals diagnosed with FD. This will explore more cost-effective therapeutic management in diseases like FD, which is believed to be related to the gut-brain axis. Meditation is a nonpharmacological therapy, safer and economical, and its adjuvant use can minimize or avoid the adverse effects of long-term use of proton pump inhibitors (PPI) and tricyclic antidepressants (TCA).

Objectives: We wanted to comprehensively assess the role of meditation as an adjuvant therapy in patients with FD and compare it with the control arm receiving standard treatment alone. The primary objective was the change in gastrointestinal quality of life index (GIQLI) score, and the secondary objective was to assess the changes in the hospital anxiety and depression scale (HADS) score and Pittsburgh sleep quality index (PSQI) score before and after the intervention.

Methods: Patients fulfilling the inclusion criteria were divided equally into two arms (experimental and control groups). The experimental group received standard treatment for dyspepsia (PPI, domperidone, TCAs) and Vaishvanara Agni meditation (VAM), while the control group received standard treatment alone. Both groups were compared at weeks 0, 4, and 8 in terms of change in GIQLI score, HADS (HADS-A and HADS-D score), and PSQI score.

Results: Our study showed that both groups experienced significant changes in GIQLI, HADS-A, HADS-D, and PSQI scores at 4 and 8 weeks when compared with the baseline time point. However, when both groups were directly compared, it was observed that the experimental group exhibited notable variations in the GIQLI score after 8 weeks, the HADS-D score after 8 weeks, and the PSQI score after 4 weeks when contrasted with the control group. These differences were found to be statistically significant.

Conclusion: FD does not have an identified structural or biochemical cause, making it a functional gastrointestinal (GI) disorder that requires a tailored treatment approach. Our pilot randomized controlled trial (RCT) investigated the impact of meditation as adjuvant therapy for FD, revealing improvements in GI health, mental well-being, and sleep quality compared to standard treatment alone. The study recommends incorporating meditation into the management of FD and similar conditions, highlighting its holistic nature that addresses not only specific symptoms but also overall well-being. This study pioneers the examination of meditation as a complementary approach for FD, offering promising results in improving GIQLI, HADS, and PSQI scores and thus adding value to preexisting literature.

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