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IF 2.1 4区医学 Q3 MEDICAL LABORATORY TECHNOLOGY

Annals of Clinical Biochemistry Pub Date : 2025-03-14 DOI:10.1177/00045632251330749

Alberto Izquierdo Martínez, Carmen Sánchez-Palacios

引用次数: 0

摘要

脑脊液（CSF）中的生物标记物对神经系统疾病的诊断、监测和预后至关重要。本研究评估了分析前变量（尤其是容器选择）对 CSF 蛋白测量的影响。我们使用 30 份 CSF 样本，比较了无菌、无添加剂试管和无分离凝胶的肝素锂试管。肝素管中的蛋白质水平明显升高（平均差异：230.71 mg/dL，p

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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IMPORTANCE OF THE PREANALYTICAL PHASE: ELEVATION OF PROTEIN LEVELS IN CEREBROSPINAL FLUID SAMPLES DUE TO INAPPROPRIATE CONTAINERS.

Biomarkers in cerebrospinal fluid (CSF) are crucial for diagnosing, monitoring, and prognosing neurological disorders. This study evaluates the impact of preanalytical variables, particularly container choice, on CSF protein measurements. Using 30 CSF samples, we compared sterile, additive-free tubes and lithium heparin tubes without separator gel. Protein levels were significantly elevated higher in heparin tubes (mean difference: 230.71 mg/dL, p<0.001). This overestimation underscores the necessity of adhering to preanalytical protocols to avoid erroneous clinical interpretations and ensure accurate diagnostic outcomes.

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来源期刊

Annals of Clinical Biochemistry Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

5.20

自引率

4.50%

发文量

期刊介绍： Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine. Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal''s scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals. Annals of Clinical Biochemistry is also the official journal of NVKC (de Nederlandse Vereniging voor Klinische Chemie) and JSCC (Japan Society of Clinical Chemistry).