睡眠时间,中点,变异性,不规则性和代谢功能障碍相关的脂肪变性肝病。

IF 2.2 3区 医学 Q3 CLINICAL NEUROLOGY
Qingcui Wu, Fuman Song, Huijie Huang, Siting Wang, Naijian Zhang, Zhilin Li, Yuanyuan Liu, Jiageng Chen, Jun Ma
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引用次数: 0

摘要

目的:非酒精性脂肪性肝病(NAFLD)的一种新定义——活动仪衍生的睡眠参数、睡眠参数的日常偏差与代谢功能障碍相关的脂肪性肝病(MASLD)之间的关系尚不清楚。我们的目的是探讨睡眠时间、中点、变异性和不规则性与MASLD风险的关系。方法:采用2011-2014年国家健康与营养检查调查(NHANES)的数据。通过24小时活动记录仪测量,估计4- 7天的睡眠时间和中点。睡眠时间和中点标准差分别作为睡眠变异性和不规则性的指标。MASLD的诊断依据多社会德尔菲共识。肝脂肪变性定义为脂肪肝指数≥60。使用多变量加权逻辑回归模型来探索相关性并进行亚组分析。结果:共纳入5316名参与者,其中2339名患有MASLD。在调整了社会人口统计学特征、生活方式因素和抑郁症后,比较了90分钟的睡眠变异性(趋势P = 0.034)。在进一步调整其他睡眠变量后,睡眠时间较短(61分钟)(趋势P = 0.003)。结论:在MASLD的预防中,除睡眠时间外,还需要考虑睡眠不规律。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sleep Duration, Midpoint, Variability, Irregularity and Metabolic Dysfunction-Associated Steatotic Liver Disease.

Objectives: The relationship between actigraphy-derived sleep parameters, day-to-day deviations in sleep parameters, and metabolic dysfunction-associated steatotic liver disease (MASLD), a new definition of nonalcoholic fatty liver disease (NAFLD), remains unclear. We aimed to explore the associations of sleep duration, midpoint, variability and irregularity with MASLD risk.

Methods: We used data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Sleep duration and midpoint were estimated from 4 to 7 days of 24-hour actigraphy measurements. Sleep duration and midpoint standard deviation were used as indicators of sleep variability and irregularity, respectively. MASLD was diagnosed according to the multi-society Delphi consensus. Hepatic steatosis was defined as fatty liver index ≥ 60. Multivariable weighted logistic regression models were used to explore correlations and perform subgroup analyses.

Results: A total of 5,316 participants were included, of whom 2,339 had MASLD. After adjusting for socio-demographic characteristics, lifestyle factors, and depression, compared to sleep variability < 60 minutes, the odds ratio (OR) [95% confidence interval (CI)] was 1.13 (0.96-1.34) for 60-90 minutes, and 1.17 (1.00-1.38) for > 90 minutes (P for trend = .034). After further adjustment for other sleep variables, short sleep duration (<7 hours) was associated with a 24% higher risk of MASLD (OR: 1.24, 95% CI: 1.01-1.53); compared to sleep irregularity < 38 minutes, OR (95% CI) was 1.27 (1.02-1.59) for 38-61 minutes and 1.43 (1.24-1.65) for > 61 minutes (P for trend = .003).

Conclusion: In addition to sleep duration, sleep irregularity may need to be considered in the prevention of MASLD.

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来源期刊
Behavioral Sleep Medicine
Behavioral Sleep Medicine CLINICAL NEUROLOGY-PSYCHIATRY
CiteScore
7.20
自引率
3.20%
发文量
49
审稿时长
>12 weeks
期刊介绍: Behavioral Sleep Medicine addresses behavioral dimensions of normal and abnormal sleep mechanisms and the prevention, assessment, and treatment of sleep disorders and associated behavioral and emotional problems. Standards for interventions acceptable to this journal are guided by established principles of behavior change. Intending to serve as the intellectual home for the application of behavioral/cognitive science to the study of normal and disordered sleep, the journal paints a broad stroke across the behavioral sleep medicine landscape. Its content includes scholarly investigation of such areas as normal sleep experience, insomnia, the relation of daytime functioning to sleep, parasomnias, circadian rhythm disorders, treatment adherence, pediatrics, and geriatrics. Multidisciplinary approaches are particularly welcome. The journal’ domain encompasses human basic, applied, and clinical outcome research. Behavioral Sleep Medicine also embraces methodological diversity, spanning innovative case studies, quasi-experimentation, randomized trials, epidemiology, and critical reviews.
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