“MagicPlates”是一种新的976像素单片硅探测器,用于放射肿瘤学的高空间分辨率剂量测定。

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Ilia Filipev, Saree Alnaghy, Martin Carolan, Jason Paino, Marco Petasecca, Dean Cutajar, Joel Poder, Justin B. Davies, Bradley M. Oborn, Nicholas Hardcastle, Susanna Guatelli, Michael Lerch, Tomas Kron, Anatoly Rosenfeld
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引用次数: 0

摘要

目的:介绍新一代“MagicPlate”二维单片像素化半导体探测器——MagicPlate-976 (MP976)。它具有更大的阵列面积,更高的空间分辨率,并且不需要外部触发。我们对小场陡剂量梯度剂量学在放射治疗中的应用进行了全面的表征,重点是用于立体定向治疗的x射线束。方法:医用辐射物理中心研制的MP976由976个离子注入二极管组成,其总阵列面积为58 × 58 mm2的n型外延硅衬底。中心区域有“小”二极管,面积为0.2 × 0.2 mm2,间距为1毫米,外围区域有“大”二极管,面积为0.6 × 0.6 mm2,间距为2毫米。探测器以10 kGy (Co-60)为底液,使用瓦里安TrueBeam直线加速器测试灵敏度变化和剂量线性,以及每脉冲剂量和光束入射角引起的响应变化。测量输出因子、深度剂量和光束轮廓,并对参考数据进行比较。结果:在10 kGy后,“大”二极管的灵敏度下降了(74±5)%,“小”二极管的灵敏度下降了(78±7)%,DPP依赖关系在市售二极管的范围内,但在0.131-1.111 mGy/脉冲的DPP范围内,“大”二极管和“小”二极管的DPP依赖关系差异为(8.4±0.2)%。最小角响应在6 MV时为90°,10 MV时为100°,分别为76%和82%。输出因子和深度剂量响应分别在3.1%和1%的范围内与参考值吻合。在小视场80%/20%的半影测量中,6 MV FFF的偏差在0.5 mm以内,10 MV FFF的偏差在0.3 mm以内。在半最大全宽度(FWHM)的光束轮廓同意在0.5毫米以内的光束质量。结论:新型MagicPlate-976检测系统适用于小范围、大剂量梯度的剂量测定。它在中心区域提供1mm的空间分辨率,在外围提供2mm的空间分辨率,并且不依赖于场的大小。该系统的高空间和时间分辨率为复杂立体定向处理方案的无触发、无膜和时间分辨率验证和错误识别提供了新的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

High spatial resolution dosimetry for radiation oncology with “MagicPlates,” a new 976-pixel monolithic silicon detector

High spatial resolution dosimetry for radiation oncology with “MagicPlates,” a new 976-pixel monolithic silicon detector

Purpose

We introduce the next generation of “MagicPlate” 2D monolithic pixelated semiconductor detectors – MagicPlate-976 (MP976). It features a larger array area, higher spatial resolution, and does not require external triggering. We perform a comprehensive characterization for small-field steep-dose-gradient dosimetry applications in radiation therapy focusing on x-ray beams used in stereotactic treatments.

Methods

The MP976, developed by the Centre for Medical Radiation Physics, consists of 976 ion-implanted diodes on a thin n-type epitaxial silicon substrate with a total array area of 58 × 58 mm2. The central region has “small” diodes with an area of 0.2 × 0.2 mm2 and 1 mm pitch and the peripheral region has “large” diodes with an area of 0.6 × 0.6 mm2 and 2 mm pitch. The detector was primed with 10 kGy (Co-60) and tested using a Varian TrueBeam linear accelerator for sensitivity change and dose linearity, and variations in response due to dose-per-pulse and beam incidence angle. Output factors, depth dose, and beam profiles were measured and compared with reference data.

Results

After the 10 kGy, the sensitivity declined by (74 ± 5)% for “large” diodes and by (78 ± 7)% for the “small” ones, the dose-per-pulse (DPP) dependence was in the range of commercially available diodes, however, a difference in the DPP dependence between the “large” and “small” diodes of (8.4 ± 0.2)% was found in the studied DPP range from 0.131–1.111 mGy/pulse. The minimum angular response was at 90° for 6 MV and 100° for 10 MV flattened beams (76% and 82%, respectively). The output factors and depth dose response showed agreement with the reference within 3.1% and 1%, respectively. Deviation in small field 80%/20% penumbra measurements was within 0.5 mm for 6 MV FF and 0.3 mm for 10 MV FFF. Full width at half maximum (FWHM) for the beam profiles agreed within 0.5 mm for both beam qualities.

Conclusion

The new MagicPlate-976 detector system is shown to be suitable for dosimetry in small fields and steep dose gradients. It provides 1 mm spatial resolution in the central region and 2 mm on the periphery and has no dependence on the field size. The system's high spatial and temporal resolution opens new opportunities for trigger-less, film-less, and time-resolved verification and error identification for complex stereotactic treatment plans.

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来源期刊
CiteScore
3.60
自引率
19.00%
发文量
331
审稿时长
3 months
期刊介绍: Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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