{"title":"乳腺癌体积调节电弧治疗期间，硅基凝胶在皮肤表面的剂量学效应。","authors":"Tenyoh Suzuki, Shingo Ohira, Mami Ogita, Takeshi Ohta, Yuki Nozawa, Masanari Minamitani, Takuya Hayashi, Shigeki Saegusa, Toshikazu Imae, Tsuyoshi Ueyama, Atsuto Katano, Hideomi Yamashita, Weishan Chang, Keiichi Nakagawa","doi":"10.1002/acm2.70070","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Purpose</h3>\n \n <p>This study aims to quantify and compare the dosimetric effects of varying thicknesses of StrataXRT, a silicone-based gel, and other topical agents on the skin surface during volumetric modulated arc therapy (VMAT) for breast cancer.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A VMAT plan was created for breast cancer treatment using a female RANDO phantom with a prescription dose of 50 Gy in 25 fractions. The planning target volume (PTV) encompassed the left breast and the regional lymph nodes. Irradiation was performed using a 6 MV photon beam. Three topical agents (StrataXRT, Hirudoid Soft Ointment, and RINDERON-Vs Ointment) having eight thicknesses (0.0–1.5 mm) were evaluated. Dosimetry was conducted using Gafchromic EBT4 films at three anatomical locations—subclavicular, medial, and lateral aspects of the left breast.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Mean dose enhancement ratios (DERs) of 102%–116% were observed in VMAT for topical agent thicknesses of 0.1–0.5 mm, increasing to 116%–126% at 1.0 and 1.5 mm. Among the evaluated agents, StrataXRT consistently exhibited the lowest DER, with a statistically significant difference (<i>p</i> < 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>This study demonstrated that StrataXRT exhibited the lowest DER among the evaluated topical agents in VMAT for breast cancer. Thicknesses exceeding 0.5 mm potentially exceeded the threshold dose for acute skin reactions.</p>\n </section>\n </div>","PeriodicalId":14989,"journal":{"name":"Journal of Applied Clinical Medical Physics","volume":"26 6","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm2.70070","citationCount":"0","resultStr":"{\"title\":\"Dosimetric effect of silicone-based gel on skin surface during volumetric modulated arc therapy for breast cancer\",\"authors\":\"Tenyoh Suzuki, Shingo Ohira, Mami Ogita, Takeshi Ohta, Yuki Nozawa, Masanari Minamitani, Takuya Hayashi, Shigeki Saegusa, Toshikazu Imae, Tsuyoshi Ueyama, Atsuto Katano, Hideomi Yamashita, Weishan Chang, Keiichi Nakagawa\",\"doi\":\"10.1002/acm2.70070\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>This study aims to quantify and compare the dosimetric effects of varying thicknesses of StrataXRT, a silicone-based gel, and other topical agents on the skin surface during volumetric modulated arc therapy (VMAT) for breast cancer.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A VMAT plan was created for breast cancer treatment using a female RANDO phantom with a prescription dose of 50 Gy in 25 fractions. The planning target volume (PTV) encompassed the left breast and the regional lymph nodes. Irradiation was performed using a 6 MV photon beam. Three topical agents (StrataXRT, Hirudoid Soft Ointment, and RINDERON-Vs Ointment) having eight thicknesses (0.0–1.5 mm) were evaluated. Dosimetry was conducted using Gafchromic EBT4 films at three anatomical locations—subclavicular, medial, and lateral aspects of the left breast.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Mean dose enhancement ratios (DERs) of 102%–116% were observed in VMAT for topical agent thicknesses of 0.1–0.5 mm, increasing to 116%–126% at 1.0 and 1.5 mm. Among the evaluated agents, StrataXRT consistently exhibited the lowest DER, with a statistically significant difference (<i>p</i> < 0.05).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>This study demonstrated that StrataXRT exhibited the lowest DER among the evaluated topical agents in VMAT for breast cancer. Thicknesses exceeding 0.5 mm potentially exceeded the threshold dose for acute skin reactions.</p>\\n </section>\\n </div>\",\"PeriodicalId\":14989,\"journal\":{\"name\":\"Journal of Applied Clinical Medical Physics\",\"volume\":\"26 6\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-03-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/acm2.70070\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Applied Clinical Medical Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/acm2.70070\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Clinical Medical Physics","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/acm2.70070","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Dosimetric effect of silicone-based gel on skin surface during volumetric modulated arc therapy for breast cancer
Purpose
This study aims to quantify and compare the dosimetric effects of varying thicknesses of StrataXRT, a silicone-based gel, and other topical agents on the skin surface during volumetric modulated arc therapy (VMAT) for breast cancer.
Methods
A VMAT plan was created for breast cancer treatment using a female RANDO phantom with a prescription dose of 50 Gy in 25 fractions. The planning target volume (PTV) encompassed the left breast and the regional lymph nodes. Irradiation was performed using a 6 MV photon beam. Three topical agents (StrataXRT, Hirudoid Soft Ointment, and RINDERON-Vs Ointment) having eight thicknesses (0.0–1.5 mm) were evaluated. Dosimetry was conducted using Gafchromic EBT4 films at three anatomical locations—subclavicular, medial, and lateral aspects of the left breast.
Results
Mean dose enhancement ratios (DERs) of 102%–116% were observed in VMAT for topical agent thicknesses of 0.1–0.5 mm, increasing to 116%–126% at 1.0 and 1.5 mm. Among the evaluated agents, StrataXRT consistently exhibited the lowest DER, with a statistically significant difference (p < 0.05).
Conclusions
This study demonstrated that StrataXRT exhibited the lowest DER among the evaluated topical agents in VMAT for breast cancer. Thicknesses exceeding 0.5 mm potentially exceeded the threshold dose for acute skin reactions.
期刊介绍：
Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission.
JACMP will publish:
-Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500.
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