乳腺癌体积调节电弧治疗期间,硅基凝胶在皮肤表面的剂量学效应。

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Tenyoh Suzuki, Shingo Ohira, Mami Ogita, Takeshi Ohta, Yuki Nozawa, Masanari Minamitani, Takuya Hayashi, Shigeki Saegusa, Toshikazu Imae, Tsuyoshi Ueyama, Atsuto Katano, Hideomi Yamashita, Weishan Chang, Keiichi Nakagawa
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引用次数: 0

摘要

目的:本研究旨在量化和比较不同厚度的StrataXRT(一种硅基凝胶)和其他局部药物在乳腺癌体积调制电弧治疗(VMAT)期间皮肤表面的剂量学效应。方法:创建VMAT计划,使用女性RANDO幻影,处方剂量为50 Gy,分25份治疗乳腺癌。计划靶体积(PTV)包括左乳房和区域淋巴结。使用6 MV光子束照射。三种外用药物(StrataXRT,喜疗妥软膏和RINDERON-Vs软膏)有8种厚度(0.0-1.5 mm)进行评估。使用Gafchromic EBT4片在左乳房锁骨下、内侧和外侧三个解剖位置进行剂量测定。结果:局部用药厚度为0.1 ~ 0.5 mm时,VMAT平均剂量增强率为102% ~ 116%,1.0、1.5 mm时,平均剂量增强率为116% ~ 126%。在评估的药物中,StrataXRT始终表现出最低的DER,差异有统计学意义(p)。结论:本研究表明,StrataXRT在评估的乳腺癌VMAT外用药物中表现出最低的DER。厚度超过0.5 mm可能超过急性皮肤反应的阈值剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dosimetric effect of silicone-based gel on skin surface during volumetric modulated arc therapy for breast cancer.

Purpose: This study aims to quantify and compare the dosimetric effects of varying thicknesses of StrataXRT, a silicone-based gel, and other topical agents on the skin surface during volumetric modulated arc therapy (VMAT) for breast cancer.

Methods: A VMAT plan was created for breast cancer treatment using a female RANDO phantom with a prescription dose of 50 Gy in 25 fractions. The planning target volume (PTV) encompassed the left breast and the regional lymph nodes. Irradiation was performed using a 6 MV photon beam. Three topical agents (StrataXRT, Hirudoid Soft Ointment, and RINDERON-Vs Ointment) having eight thicknesses (0.0-1.5 mm) were evaluated. Dosimetry was conducted using Gafchromic EBT4 films at three anatomical locations-subclavicular, medial, and lateral aspects of the left breast.

Results: Mean dose enhancement ratios (DERs) of 102%-116% were observed in VMAT for topical agent thicknesses of 0.1-0.5 mm, increasing to 116%-126% at 1.0 and 1.5 mm. Among the evaluated agents, StrataXRT consistently exhibited the lowest DER, with a statistically significant difference (p < 0.05).

Conclusions: This study demonstrated that StrataXRT exhibited the lowest DER among the evaluated topical agents in VMAT for breast cancer. Thicknesses exceeding 0.5 mm potentially exceeded the threshold dose for acute skin reactions.

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来源期刊
CiteScore
3.60
自引率
19.00%
发文量
331
审稿时长
3 months
期刊介绍: Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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