颈椎椎间盘置换术与前路颈椎椎间盘切除术融合治疗退行性颈椎病:国家行政数据库中的患者特征和手术结果。

IF 2.6 3区 医学 Q2 CLINICAL NEUROLOGY
Charles N de Leeuw, Won Hyung Andrew Ryu, Jung Yoo, Josiah N Orina
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引用次数: 0

摘要

研究设计:采用PearlDiver患者索赔数据库的回顾性队列研究。目的颈椎间盘置换术(CDA)是治疗颈神经根病的常用方法;然而,它对脊髓病也可能是安全有效的。因此,我们比较了行CDA和前路颈椎椎间盘切除术融合(ACDF)治疗退行性颈椎病(DCM)患者的临床特征和结果。方法确定2015-2019年期间接受CDA或ACDF的患者,随访至2021年。进行单变量和多变量分析,以确定与任何一种程序相关的因素。再手术率采用倾向匹配分析进行比较。结果共鉴定出n = 2391例CDA和n = 50845例ACDF。支持CDA的因素包括:女性、年轻、较低的CCI、较低的肥胖、骨质疏松、糖尿病或吸烟发生率(P≤0.001);多变量logistic回归后,除性别外,其余均显著(P = .06)。单节段手术更能预测CDA的发生。CDA患者的90天再入院率、并发症和阿片类药物使用率较低。总再手术率为5%。再手术的预测因素包括:男性、年龄小、CCI大、肥胖、骨质疏松、糖尿病、吸烟和多级别手术;多变量分析后,除糖尿病(P = .23)和CCI (P = .05)外,其余均显著。经倾向匹配的CDA和ACDF患者(n = 2391),再手术率无差异(P = 0.47)。结论scda患者更健康(肥胖、吸烟、糖尿病较少,CCI较好),占DCM前路手术的4.5%。在单变量分析中,CDA患者的再入院率、医疗并发症和阿片类药物使用较低,尽管再手术率相似。考虑到这些发现,CDA可能非常有选择性地用于DCM。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cervical Disc Arthroplasty Versus Anterior Cervical Discectomy and Fusion in the Treatment of Degenerative Cervical Myelopathy: Patient Characteristics and Surgical Outcomes in a National Administrative Database.

Study DesignA retrospective cohort utilizing the PearlDiver Patient Claims Database.ObjectiveCervical disc arthroplasty (CDA) is accepted treatment for cervical radiculopathy; however, it may also be safe and effective in myelopathy. Thus, we compared clinical characteristics and outcomes in patients undergoing CDA and anterior cervical discectomy and fusion (ACDF) for degenerative cervical myelopathy (DCM) specifically.MethodsPatients undergoing CDA or ACDF between 2015-2019 were identified with follow-up through 2021. Univariate and multivariable analyses were performed to identify factors associated with either procedure. Reoperation rates were compared using propensity-matched analysis.ResultsWe identified n = 2391 CDA and n = 50 845 ACDF procedures for DCM. Factors favoring CDA included: female sex, younger age, lower CCI, lower incidence of obesity, osteoporosis, diabetes, or smoking (P ≤ .001); remaining significant after multivariable logistic regression except for sex (P = .06). Single-level surgery was more predictive for undergoing CDA. CDA patients had lower 90-day readmissions, complications, and lower opioid utilization. The overall reoperation rate was 5%. Predictors of reoperation included: male sex, younger age, greater CCI, obesity, osteoporosis, diabetes, smoking, and multi-level surgery; all remaining significant after multivariable analysis except for diabetes (P = .23) and CCI (P = .05). After propensity-matching CDA and ACDF patients (n = 2391), there was no difference in re-operation rates (P = .47).ConclusionsCDA patients were healthier (less obesity, smoking, diabetes, better CCI) and represented 4.5% of anterior procedures for DCM. In univariate analysis, readmission rates, medical complications, and opioid use were lower in CDA patients, despite a similar reoperation rate. Considering these findings, CDA might be used very selectively for DCM.

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来源期刊
Global Spine Journal
Global Spine Journal Medicine-Surgery
CiteScore
6.20
自引率
8.30%
发文量
278
审稿时长
8 weeks
期刊介绍: Global Spine Journal (GSJ) is the official scientific publication of AOSpine. A peer-reviewed, open access journal, devoted to the study and treatment of spinal disorders, including diagnosis, operative and non-operative treatment options, surgical techniques, and emerging research and clinical developments.GSJ is indexed in PubMedCentral, SCOPUS, and Emerging Sources Citation Index (ESCI).
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