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IF 3.4 2区医学 Q2 ONCOLOGY

BMC Cancer Pub Date : 2025-03-13 DOI:10.1186/s12885-025-13443-2

Uzma Shamsi, Muhammad Shahzaib Arshad, Yasmin Abdul Rashid, Hamzah Jehanzeb, Hamdan Ahmed Pasha

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引用次数: 0

摘要

导言：巴基斯坦的口腔癌（OCC）发病率很高，复发率也很高。本研究旨在探讨与巴基斯坦卡拉奇口腔癌复发相关的因素：这项横断面研究在巴基斯坦卡拉奇阿迦汗大学医院（AKUH）进行，使用的数据来自 AKUH 癌症登记处。研究共纳入了 1692 例经活检确诊的 OCC 病例，包括 2011 年 5 月至 2020 年 12 月期间确诊的唇粘膜癌、舌癌、牙龈癌、口腔底癌、腭癌和其他亚部位（如齿龈后区域）癌症：在1692名患者中，有611人（36.1%）复发。与女性相比，男性的OCC复发几率明显增加（患病率比（POR）= 1.70，95% CI = 1.25-2.30）。中度和分化不良肿瘤的复发几率更高（POR = 1.44，95% CI = 1.02-2.02 和 POR = 2.35，95% CI = 1.49-3.71）。淋巴结受累与复发几率增加明显相关。N1、N2和N3淋巴结受累的患者复发几率明显更高（N1淋巴结受累的POR=1.45，95% CI=1.02-2.07；N2淋巴结受累的POR=2.12，95% CI=1.57-2.87；N3淋巴结受累的POR=3.50，95% CI=1.72-7.11）。在 AKUH 以外进行手术治疗与较高的 OCC 复发率相关（POR = 1.68，95% CI = 1.12-2.50）。单独手术（POR = 0.02，95% CI = 0.00-0.16）和联合放疗（POR = 0.02，95% CI = 0.00-0.16）或化疗（POR = 0.04，95% CI = 0.01-0.33）对复发有保护作用：本研究发现了增加口腔癌复发的因素，强调了在管理和随访口腔癌患者时考虑这些因素的重要性。了解这些因素不仅有助于加强对患者的护理，还能改善对患者的疾病预后教育。我们需要进一步开展研究，探索其潜在机制并制定有针对性的干预措施，以改善 OCC 患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Determinants of oral cavity cancer recurrence in Pakistan: findings from a cross-sectional study using an institutional cancer registry.

Introduction: Pakistan has a high prevalence of oral cavity cancer (OCC) with a significant recurrence rate. This study aims to explore the factors associated with OCC recurrence in Karachi, Pakistan.

Methods: This cross-sectional study was conducted at the Aga Khan University Hospital (AKUH) Karachi, Pakistan, using data from the AKUH Cancer Registry. A total of 1692 biopsy-confirmed cases of OCC including cancers of mucosal lip, tongue, gum, oral cavity floor, palate and other subsites like retromolar area, diagnosed between May 2011 and December 2020, were included in our study.

Results: Of the 1692 patients, 611 (36.1%) experienced recurrence. Being male was associated with significantly increased odds of OCC recurrence compared to being female (Prevalence Odds Ratio (POR) = 1.70, 95% CI = 1.25-2.30). Moderately and poorly differentiated tumors had higher odds of recurrence (POR = 1.44, 95% CI = 1.02-2.02 and POR = 2.35, 95% CI = 1.49-3.71 respectively). Lymph node involvement was significantly associated with increased odds of recurrence. Patients with N1, N2 and N3 lymph node involvement had significantly higher odds of recurrence (POR = 1.45, 95% CI = 1.02-2.07 for N1, POR = 2.12, 95% CI = 1.57-2.87 for N2 and POR = 3.50, 95% CI = 1.72-7.11 for N3 respectively). Surgical treatment outside AKUH was associated with higher OCC recurrence (POR = 1.68, 95% CI = 1.12-2.50). Surgery alone (POR = 0.02, 95% CI = 0.00-0.16) and in combination with radiation (POR = 0.02, 95% CI = 0.00-0.16) or chemoradiation (POR = 0.04, 95% CI = 0.01-0.33) was protective against recurrence.

Conclusion: This study's findings identified factors increasing oral cavity cancer recurrence, highlighting the importance of considering these factors in the management and follow up of patients with OCC. Understanding these factors will not only help enhance patient care, but also improve patient education about their disease prognosis. Further research is needed to explore the underlying mechanisms and develop targeted interventions to improve outcomes for patients with OCC.

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来源期刊

BMC Cancer 医学-肿瘤学

CiteScore

6.00

自引率

2.60%

发文量

1204

审稿时长

6.8 months

期刊介绍： BMC Cancer is an open access, peer-reviewed journal that considers articles on all aspects of cancer research, including the pathophysiology, prevention, diagnosis and treatment of cancers. The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and clinical trials.