澳大利亚一个国家级胰腺移植单位 30 年来的胰腺移植历史、演变和手术效果。

IF 1.5 4区 医学 Q3 SURGERY
David S C Soon, Dennison Cheung, David Scott, Erwin Yii, Alan Saunder, Roger Bell, Stephen Thwaites, William Mulley, John Kanellis, Ming Kon Yii
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摘要

本文章由计算机程序翻译,如有差异,请以英文原文为准。
30 years of history, evolution, and surgical outcomes of pancreas transplants in a single Australian national pancreatic transplant unit.

Background: The first pancreas transplant in Australia was performed at Prince Henry's Hospital in 1984 (which subsequently relocated to Monash Medical Centre in 1992) in the setting of a successful pancreas transplant reported from the University of Minnesota in 1966.1 This study is aimed at reviewing the evolution of surgical technique in pancreas transplants and the surgical outcomes.

Methods: All pancreas transplants were reviewed from 1992 to 2022. The evolution of surgical technique for pancreas transplants were collected. Outcomes include graft associated complications such as graft thrombosis rate, pancreas graft survival rate, and length of stay.

Results: Forty-four pancreas transplants were done from 1992 to 2001, following that from 2002 to 2022 that number increased to 236 transplants. Venous drainage went from systemic to portal and subsequently reverted to systemic with modification, directly into the inferior vena cava (IVC). The rate of Early pancreatic allograft thrombosis (EPAT) in the institution was (3/18, 17% Common iliac vein (CIV), 3/19, 16% External iliac vein (EIV) and 1/7, 14% Superior Mesenteric Vein (SMV) from 1992 to 2001 and subsequently reduced to 7/119, 5.9% (IVC.) 5/19, 23.3% (CIV), 6/23, 26.1% (EIV), and 10/75, 13.3% (SMV) after modification. The average length of stay of patients in the first cohort was 18.1 days and the subsequent group was 15.5 days. Finally, pancreatic graft survival rates were 77.3% 1-year graft survival and 54.6% 5-year graft survival from 1992 to 2001 and 93.5% 1-year graft survival and 80.6% 5-year graft survival from 2002 to 2022.

Conclusion: Pancreas transplants are complex and technically demanding procedures that should be performed within a specialized unit.

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来源期刊
ANZ Journal of Surgery
ANZ Journal of Surgery 医学-外科
CiteScore
2.50
自引率
11.80%
发文量
720
审稿时长
2 months
期刊介绍: ANZ Journal of Surgery is published by Wiley on behalf of the Royal Australasian College of Surgeons to provide a medium for the publication of peer-reviewed original contributions related to clinical practice and/or research in all fields of surgery and related disciplines. It also provides a programme of continuing education for surgeons. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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