对脓肿分枝杆菌具有有效协同作用的三联抗菌药物组合。

IF 4.1 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2025-04-02 Epub Date: 2025-03-14 DOI:10.1128/aac.01828-24

Yanqin Huang, Lucius Chiaraviglio, Ibidunni Bode-Sojobi, James E Kirby

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引用次数: 0

摘要

使用二维和三维棋盘分析法对当代脓肿分枝杆菌分离物进行抗菌组合的协同作用测试。奥马大环素-阿奇霉素-氯法齐明、替加环素-阿奇霉素-氯法齐明、奥马大环素-阿奇霉素-利奈唑胺和奥马大环素-阿奇霉素-康替唑胺三联用药分别对33%、31%、62%和66%的分离菌表现出协同作用（分数抑制浓度指数≤0.5）。值得注意的是，在所有三联用药中，耐大环内酯的脓肿分枝杆菌亚种。脓杆菌和脓杆菌亚种。在FIC指数上，bolletii分离株对阿奇霉素完全敏感，氯法齐明mic升高的分离株也是如此。

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Triple antimicrobial combinations with potent synergistic activity against M. abscessus.

Synergy of antimicrobial combinations was tested against contemporary Mycobacteroides abscessus isolates using 2D and 3D checkerboard assays. Triple combinations of omadacycline-azithromycin-clofazimine, tigecycline-azithromycin-clofazimine, omadacycline-azithromycin-linezolid, and omadacycline-azithromycin-contezolid demonstrated synergy (fractional inhibitory concentration index ≤ 0.5) against 33%, 31%, 62%, and 66% of isolates, respectively. Notably, in all triple combinations, macrolide-resistant M. abscessus subsp. abscessus and M. abscessus subsp. bolletii isolates were fully sensitized to azithromycin at the FIC index, as were isolates with elevated clofazimine MICs.

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.