L-和d -乳酸:揭示它们在疾病和健康中的隐藏功能。

IF 8.2 2区 生物学 Q1 CELL BIOLOGY
Jianting Li, Peng Ma, Zhizhen Liu, Jun Xie
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引用次数: 0

摘要

乳酸,曾经被认为仅仅是无氧代谢的副产物,现在被认为是一个重要的信号分子,在生理和病理中具有多种作用。乳酸有两种立体异构体:L-乳酸和d -乳酸。最近的研究表明,这两种乳酸立体异构体的破坏对健康和疾病有明显的影响。l -乳酸是糖酵解和Cori循环能量传递的核心,也是糖酵解诱导的主要乳酸化异构体,影响代谢和细胞存活。虽然研究较少,但d -乳酸与代谢紊乱有关,并在线粒体功能障碍和氧化应激中发挥作用。本文综述了L-乳酸和d -乳酸,并探讨了它们在生理和病理过程中的生物合成、转运和扩展作用,特别是它们在癌症、免疫调节、炎症、神经变性和其他疾病中的功能。最后,我们评估了靶向乳酸代谢的治疗前景,强调了在临床环境中干预的新兴策略。我们的综述综合了目前对L-和d -乳酸盐的理解,提供了对它们作为治疗创新靶点的潜力的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
L- and D-Lactate: unveiling their hidden functions in disease and health.

Lactate, once considered a mere byproduct of anaerobic metabolism, is now recognized as a critical signaling molecule with diverse roles in physiology and pathology. There are two stereoisomers of lactate: L- and D-lactate. Recent studies have shown that disruptions in these two lactate stereoisomers have distinct effects on health and disease. L-lactate is central to glycolysis and energy transfer through the Cori cycle but also acts as the dominant lactylation isomer induced by glycolysis, influencing metabolism and cell survival. Although less studied, D-lactate is linked to metabolic disorders and plays a role in mitochondrial dysfunction and oxidative stress. This review focuses on both L- and D-lactate and examines their biosynthesis, transport, and expanding roles in physiological and pathological processes, particularly their functions in cancer, immune regulation, inflammation, neurodegeneration and other diseases. Finally, we assess the therapeutic prospects of targeting lactate metabolism, highlighting emerging strategies for intervention in clinical settings. Our review synthesizes the current understanding of L- and D-lactate, offering insights into their potential as targets for therapeutic innovation.

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来源期刊
CiteScore
11.00
自引率
0.00%
发文量
180
期刊介绍: Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.
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