系统性红斑狼疮患者虚弱和虚弱前期的患病率：系统回顾与荟萃分析

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-03-06 DOI:10.1016/j.semarthrit.2025.152709

Ni Sang , Hong-hui Zhang , Meng-yao Zhang , Ming-hui Zhang , Yan-qin Zhu , Hui Chen , You Sun , Meng-cheng Cheng , Guo-cui Wu

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引用次数: 0

摘要

目的：虚弱与系统性红斑狼疮（SLE）的死亡率相关，但患病率尚不清楚。本系统综述和荟萃分析的目的是调查SLE患者虚弱和易感的患病率。方法系统检索PubMed、Cochrane、EMBASE和Web of Science四个数据库，从数据库建立到2024年11月，以确定符合系统评价和荟萃分析预设的先验纳入标准，并专门研究SLE患者的脆弱性和易感性的研究。根据纽卡斯尔-渥太华量表（NOS）对纳入的研究进行质量评估。结果根据纳入标准检索到15项研究，并将其数据合并到最终的综述中。数据来自46060例SLE患者。分析显示，SLE患者虚弱的总患病率为27% (95% CI: 19% - 36%)，虚弱的总患病率为65% （95% CI: 54% - 76%）。亚组分析显示，系统性狼疮国际合作诊所-衰弱指数（SLICC-FI）测量的衰弱患病率为26% (95% CI: 14%至41%)，使用Fried表型（FP）评估的衰弱患病率为22% （95% CI: 18%至26%）。结论虚弱和易感是SLE患者普遍存在的症状。迫切需要更好地了解和解决这一人群的脆弱性，以提高患者的预后和生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Prevalence of frailty and prefrailty in systemic lupus erythematosus: A systematic review and meta-analysis

查看原文本刊更多论文

Prevalence of frailty and prefrailty in systemic lupus erythematosus: A systematic review and meta-analysis

Objective

Frailty is associated with mortality in systemic lupus erythematosus (SLE), but the prevalence is unclear. The aim of this systematic review and meta-analysis was to investigate the prevalence of frailty and prefrailty in SLE patients.

Methods

Four databases, namely PubMed, Cochrane, EMBASE, and Web of Science, were systematically searched from their inception to November 2024 to identify studies that fulfilled the predefined a priori inclusion criteria for systematic review and meta-analysis, and that specifically investigated frailty and prefrailty in patients with SLE. The quality assessment of the included studies was conducted according to the Newcastle-Ottawa scale (NOS).

Results

Fifteen studies were retrieved according to the inclusion criteria, and their data were combined in the eventual review. Data from studies including 46,060 patients with SLE were included. The analysis showed that the pooled prevalence of frailty in patients with SLE was 27 % (95 % CI: 19 % - 36 %), the pooled prevalence of prefrailty was 65 % (95 % CI: 54 % - 76 %). Analysis of subgroups revealed that the prevalence of frailty was 26 % (95 % CI: 14 % to 41 %) when measured by Systemic Lupus International Collaborating Clinics-Frailty Index (SLICC-FI) and 22 % (95 % CI: 18 % to 26 %) when assessed using Fried phenotype (FP).

Conclusion

Both frailty and prefrailty are highly prevalent conditions among patients with SLE. There is an urgent need to better understand and address frailty in this population to enhance patient outcomes and quality of life.

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.