微藻甾醇和生物合成相关骨架重排枞烷的生物启发合成

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-28 DOI:10.1021/acs.orglett.5c0003310.1021/acs.orglett.5c00033

Ling Huang, Peng Wang, Fan Xia, Lu Chen, Wengui Wang*, Gang Xu* and Jun Deng*,

引用次数: 0

摘要

我们报道了一种从市售鼠尾草酸中合成微藻甾醇和生物合成相关的骨架重排枞烷二萜的生物启发合成。该策略的特点是Wagner-Meerwein型甲基迁移，随后是几个级联转化，使五种abietane二萜类化合物的不同合成成为可能，包括viridoquinone， prattinin a, saprorthoquinone， microstegiol和1-deoxyviroxocin。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bioinspired Synthesis of Microstegiol and Biosynthetically Related Skeleton-Rearranged Abietanes

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Bioinspired Synthesis of Microstegiol and Biosynthetically Related Skeleton-Rearranged Abietanes

We report a bioinspired synthesis of microstegiol and biosynthetically related skeleton-rearranged abietane diterpenoids from commercially available carnosic acid. The strategy features a Wagner–Meerwein type methyl migration followed by several cascade transformations, enabling the divergent synthesis of five abietane diterpenoids, including viridoquinone, prattinin A, saprorthoquinone, microstegiol, and 1-deoxyviroxocin.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.