NEMO/ATM/IKKα复合物：结直肠癌进展和治疗的关键参与者

IF 7.3 1区生物学

Science Signaling Pub Date : 2025-03-11 DOI:10.1126/scisignal.adv1265

Neil D Perkins

引用次数: 0

摘要

激酶IKKα磷酸化激酶ATM，增强其促进DNA修复的能力。在本期《Science Signaling》中，Alonso-Marañón等人证明，在结直肠癌细胞中，IKK调控亚基NEMO将ATM/IKKα复合物靶向DNA损伤位点，从而增强DNA修复和化疗耐药性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The NEMO/ATM/IKKα complex: A key player in colorectal cancer progression and treatment.

The kinase IKKα phosphorylates the kinase ATM, enhancing its ability to promote DNA repair. In this issue of Science Signaling, Alonso-Marañón et al. demonstrate that in colorectal cancer cells, the IKK regulatory subunit NEMO targets the ATM/IKKα complex to sites of DNA damage, thus enhancing DNA repair and chemotherapy resistance.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Science Signaling Biochemistry, Genetics and Molecular Biology-Molecular Biology

自引率

0.00%

发文量

148

期刊介绍： Science Signaling is a weekly, online multidisciplinary journal dedicated to the life sciences. Our editorial team's mission is to publish studies that elucidate the fundamental mechanisms underlying biological processes across various organisms. We prioritize research that offers novel insights into physiology, elucidates aberrant mechanisms leading to disease, identifies potential therapeutic targets and strategies, and characterizes the effects of drugs both in vitro and in vivo.