IF 2.5 4区 医学 Q3 GENETICS & HEREDITY
Mutagenesis Pub Date : 2025-03-11 DOI:10.1093/mutage/geaf007
Shabir Ahmad Rather, Zahoor Ahmad Wani, Rashaid Ali Mustafa, Pooja Bharti, Rukhsana Kousar, Mohammad Vikas Ashraf, Shoeb Ahmad, A A Shah, M A Hannan Khan
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引用次数: 0

摘要

自然,广泛的遗传和环境变量占主导地位,如细菌、病毒和寄生虫感染实体,已被确定为致癌生物试剂。许多蠕虫和原生动物寄生虫病都可能导致人类癌症。据报道,三种吸虫寄生虫,即血吸虫、Opisthorchis viverrini 和 Clonorchis sinensis 与人类癌症有内在联系。针对其他寄生虫感染的类似研究仍不精确,需要进一步验证。尽管疟疾不致癌,但恶性疟原虫可导致全流行性伯基特淋巴瘤。这篇综述介绍了寄生虫感染致癌的相关性和内在机制。本文提供的经验文献涵盖了病毒、细菌和寄生虫致癌的流行率和发病率。此外,还总结了寄生虫致癌的一些可能的诊断和治疗方法。本文附录详细介绍了通过不同途径导致致癌的各种突变和遗传变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Carcinogenic parasites: Insights into the epidemiology and possible mechanisms of cancer.

Naturally, a wide range of genetic and environmental variables predominate, such as bacterial, viral and parasite infective entities that have been identified as carcinogenic bioagents. Many helminth and protozoan parasitic diseases are liable to cause human cancer. Conveniently, three trematode parasites viz. Schistosoma haematobium, Opisthorchis viverrini and Clonorchis sinensis have been reported to be intrinsically linked with human cancer. Similar studies for other parasitic infections are still imprecise and need further validation. Plasmodium falciparum is known to cause holoendemic Burkitt lymphoma despite non-carcinogenic role of malaria. This review is endowed with a coupled correlation and underlying mechanisms by which parasitic infections lead to carcinogenicity. An empirical documentation covering the prevalence and incidence of viral, bacterial and parasitic carcinogenicity is illustrated in this article. Moreover, some probable diagnostic and treatment procedures for parasitic carcinogenicity are also summarized. A detailed account of various mutational and genetic changes that lead to carcinogenesis via different pathways is appended in this article.

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来源期刊
Mutagenesis
Mutagenesis 生物-毒理学
CiteScore
5.90
自引率
3.70%
发文量
22
审稿时长
6-12 weeks
期刊介绍: Mutagenesis is an international multi-disciplinary journal designed to bring together research aimed at the identification, characterization and elucidation of the mechanisms of action of physical, chemical and biological agents capable of producing genetic change in living organisms and the study of the consequences of such changes.
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