Cassidy J Tomlinson, Laura Ryniker, Haley M Cook, Rebecca M Schwartz, Amy L Non
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Exploratory regression analyses were conducted with DNAm in relation to trauma exposure, mental health symptoms, and coping strategies.</p><p><strong>Results: </strong>Higher DNAm at one site of SLC6A4 was associated with lower levels of anxiety (B = -0.62 (SE = 0.23), <i>p</i> = 0.0109), depression (B = -0.06 (SE = 0.03), <i>p</i> = 0.0435), and PTSD symptoms at baseline (B = -0.03 (SE = 0.01), <i>p</i> = 0.0374). DNAm at FKBP5 was negatively associated with measures of anxiety (B = -0.30 (SE = 0.07), <i>p</i> = 0.0001) and depression symptoms (B = -0.2 (SE = 0.10), <i>p</i> = 0.0103). Various coping strategies were also associated with sites in both genes across time points, e.g. self-blame and substance use.</p><p><strong>Conclusion: </strong>Our findings generate intriguing hypotheses linking mental health symptoms and DNA methylation, to be replicated with larger samples.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"297-307"},"PeriodicalIF":3.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970741/pdf/","citationCount":"0","resultStr":"{\"title\":\"Epigenetics in persons living with HIV: trauma, coping, and <i>FKBP5</i> and <i>SLC6A4</i> methylation.\",\"authors\":\"Cassidy J Tomlinson, Laura Ryniker, Haley M Cook, Rebecca M Schwartz, Amy L Non\",\"doi\":\"10.1080/17501911.2025.2476389\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>People living with HIV (PLWH) have an increased risk for lifetime trauma and mental health difficulties. 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DNAm at FKBP5 was negatively associated with measures of anxiety (B = -0.30 (SE = 0.07), <i>p</i> = 0.0001) and depression symptoms (B = -0.2 (SE = 0.10), <i>p</i> = 0.0103). 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引用次数: 0
摘要
目的：艾滋病毒感染者（PLWH）终生遭受创伤和精神健康困难的风险增加。然而，没有研究评估压力相关基因与PLWH患者早期生活逆境、终生创伤或创伤后应激障碍（PTSD）的关系。方法：使用亚硫酸氢盐磷酸测序，我们评估了从HIV项目中随机招募的70名PLWH和51名个体的全血中FKBP5（糖皮质激素反馈调节因子）7内含子和SLC6A4（血清素转运基因）启动子的DNA甲基化（DNAm）。探索性回归分析了DNAm与创伤暴露、心理健康症状和应对策略的关系。结果：SLC6A4某一位点较高的DNAm与较低水平的焦虑（B = -0.62 (SE = 0.23), p = 0.0109）、抑郁（B = -0.06 (SE = 0.03), p = 0.0435）和基线PTSD症状（B = -0.03 (SE = 0.01), p = 0.0374）相关。FKBP5的DNAm与焦虑（B = -0.30 (SE = 0.07), p = 0.0001）和抑郁症状（B = -0.2 (SE = 0.10), p = 0.0103）呈负相关。不同的应对策略也与两个基因在不同时间点上的位点有关，例如自责和物质使用。结论：我们的发现产生了有趣的假设，将精神健康症状和DNA甲基化联系起来，并将在更大的样本中得到复制。
Epigenetics in persons living with HIV: trauma, coping, and FKBP5 and SLC6A4 methylation.
Aim: People living with HIV (PLWH) have an increased risk for lifetime trauma and mental health difficulties. However, no studies have evaluated stress-related genes in relation to early-life adversity, lifetime trauma, or post-traumatic stress disorder (PTSD) in PLWH.
Methods: Using bisulfite pyrosequencing, we evaluated DNA methylation (DNAm) in intron 7 of FKBP5, a glucocorticoid feedback regulator, and in the promoter of SLC6A4, the serotonin transporter gene, in whole blood of a random sample of 70 PLWH recruited from an HIV program, and 51 individuals 2 years later (n = 48 at both time points). Exploratory regression analyses were conducted with DNAm in relation to trauma exposure, mental health symptoms, and coping strategies.
Results: Higher DNAm at one site of SLC6A4 was associated with lower levels of anxiety (B = -0.62 (SE = 0.23), p = 0.0109), depression (B = -0.06 (SE = 0.03), p = 0.0435), and PTSD symptoms at baseline (B = -0.03 (SE = 0.01), p = 0.0374). DNAm at FKBP5 was negatively associated with measures of anxiety (B = -0.30 (SE = 0.07), p = 0.0001) and depression symptoms (B = -0.2 (SE = 0.10), p = 0.0103). Various coping strategies were also associated with sites in both genes across time points, e.g. self-blame and substance use.
Conclusion: Our findings generate intriguing hypotheses linking mental health symptoms and DNA methylation, to be replicated with larger samples.
期刊介绍：
Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community.
Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
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