奥马达环素体外抗棒状杆菌活性评价。

IF 4.1 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2025-04-02 Epub Date: 2025-03-12 DOI:10.1128/aac.01864-24

Saltanat Ualiyeva, Justin McCallum, Alexander Donald Pyden, Zoe Freeman Weiss

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引用次数: 0

摘要

棒状杆菌是革兰氏阳性细菌，越来越被认为是病原体。本研究采用微量肉汤稀释法（BMD）和Liofilchem omadacycline MIC试纸条（MTS）两种方法，评估了四环素奥马达环素（omadacycline，一种四环素）对40株临床杆状杆菌分离株的MIC。通过BMD测定，MIC50、MIC90和MIC范围分别为0.5µg/mL、1µg/mL和0.12 ~ 2.0µg/mL。BMD与MTS比较，基本一致性（EA，参考BMD MIC稀释±1倍）为87.5% （95% CI: 73.0%-95.4%）。

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Evaluation of omadacycline in vitro activity against Corynebacterium species.

Corynebacterium spp. are gram-positive bacteria increasingly recognized as pathogens. This study evaluates the MICs of omadacycline, a tetracycline, against 40 clinical Corynebacterium isolates using two methodologies: broth microdilution (BMD) and Liofilchem omadacycline MIC Test Strip (MTS). By BMD, the MIC₅₀, MIC₉₀, and MIC range were 0.5 µg/mL, 1 µg/mL, and 0.12-2.0 µg/mL, respectively. Comparing BMD to MTS, essential agreement (EA, within ±1 doubling dilution of the reference BMD MIC) was 87.5% (95% CI: 73.0%-95.4%).

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.