姜黄素负载聚(ε-己内酯)/牛血清白蛋白复合纤维的无表面活性剂乳液静电纺丝研究

IF 2.5 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
Peng-Hui Zhu, Shu-Hua Teng, Peng Wang
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引用次数: 0

摘要

采用新型环保的乙酸乙酯/水溶剂体系制备了负载姜黄素(Cur)的聚ε-己内酯(PCL)/牛血清白蛋白(BSA)的油包水(W/O)乳液,无需添加表面活性剂。乳状液液滴大小随BSA浓度的升高而减小,随OTW体积比的减小而增大。静电纺丝后,随着BSA浓度从0% (w/v)增加到10% (w/v),负载cu的PCL/BSA复合材料的形貌由珠状结构转变为均匀纤维。随着OTW体积比的增大,复合纤维的直径增大,形貌一致。当OTW体积比为7:3时,纤维的弹性模量最高(0.198 MPa),断裂伸长率最高(199%),拉伸强度最大(3.83 MPa)。值得注意的是,BSA的存在导致了复合纤维的超亲水性。此外,所有复合纤维均表现出持续的药物释放行为,特别是当OTW体积比为7:3时,其释放行为最符合一阶模型。本研究有望进一步完善疏水性聚乳酸的生物功能,扩大其在生物医学领域的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Surfactant-free emulsion electrospinning of curcumin-loaded poly(ε-caprolactone)/bovine serum albumin composite fibers for biomedical applications

A novel and eco-friendly ethyl acetate/water solvent system was employed to create stable water-in-oil (W/O) emulsions of curcumin (Cur)-loaded poly(ε-caprolactone) (PCL)/bovine serum albumin (BSA) without the need for surfactants. The size of emulsion droplets decreased with the rise of the BSA concentration but increased with the drop of the oil-to-water (OTW) volume ratio. Upon electrospinning, the morphology of Cur-loaded PCL/BSA composites transformed from bead-like structures to uniform fibers as the BSA concentration rose from 0% (w/v) to 10% (w/v). With the enhancement of the OTW volume ratio, the composite fibers displayed an increased diameter and a consistently uniform morphology. The highest modulus of elasticity (0.198 MPa) and the largest elongation at break (199%) of fibers were achieved at the OTW volume ratio of 7:3, while the maximum tensile strength (3.83 MPa) was obtained at 8:2. Notably, the presence of BSA resulted in the superhydrophilicity of composite fibers. Moreover, all composite fibers exhibited sustained drug release behaviors, especially for those with the OTW volume ratio of 7:3, the release behavior of which was the best to match the first-order model. This study is expected to improve biofunctions of hydrophobic PCL and expand its applications in biomedical fields.

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来源期刊
Frontiers of Materials Science
Frontiers of Materials Science MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
4.20
自引率
3.70%
发文量
515
期刊介绍: Frontiers of Materials Science is a peer-reviewed international journal that publishes high quality reviews/mini-reviews, full-length research papers, and short Communications recording the latest pioneering studies on all aspects of materials science. It aims at providing a forum to promote communication and exchange between scientists in the worldwide materials science community. The subjects are seen from international and interdisciplinary perspectives covering areas including (but not limited to): Biomaterials including biomimetics and biomineralization; Nano materials; Polymers and composites; New metallic materials; Advanced ceramics; Materials modeling and computation; Frontier materials synthesis and characterization; Novel methods for materials manufacturing; Materials performance; Materials applications in energy, information and biotechnology.
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