时间和季节变化对支气管扩张剂反应性的影响：SPIRO-TIMETRY研究

IF 9 1区医学 Q1 RESPIRATORY SYSTEM

Thorax Pub Date : 2025-03-11 DOI:10.1136/thorax-2024-222773

Ben Knox-Brown, Fu Chuen Kon, Karl Peter Sylvester, Akhilesh Jha

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引用次数: 0

摘要

我们调查了在医院为基础的人群中，一天中的时间和季节对支气管扩张剂反应水平的检测之间的关系。我们发现，在工作日中每增加1小时，支气管扩张剂阳性反应的几率降低8%。当一天的时间被分为上午和下午时，也看到了类似的效果。当按转诊原因分层时，一天中时间的影响仅在那些转诊为哮喘/查询哮喘的患者中可见。我们还发现，与一年中的其他月份相比，支气管扩张剂反应在冬季更为常见。

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Effect of time of day and seasonal variation on bronchodilator responsiveness: the SPIRO-TIMETRY study

We investigated the association between time of day and season of testing on the level of bronchodilator responsiveness in a hospital-based population. We found that per 1-hour increment in the working day, the odds of a positive bronchodilator response decreased by 8%. A similar effect was seen when time of day was dichotomised into morning and afternoon time periods. When stratifying by referral reason, the impact of time of day was only seen in those referred for asthma/query asthma. We also found that bronchodilator responsiveness was more common in winter months compared with the rest of the year.

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来源期刊

Thorax 医学-呼吸系统

CiteScore

16.10

自引率

2.00%

发文量

197

审稿时长

1 months

期刊介绍： Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.