Francesco Bertola, Salvatore Micali, Marco Ticonosco, Enrico Ioverno, Enzo Dal Lago, Andrea Busolo, Rafael Ramirez Morales, Grazia Buonfantino, Alessandro Di Giorgi, Francesco Paolo Busardò, Katsiaryna Nikitsenka, Giuliana Ruggero, Michela Zamboni, Giuliano Fin, Emanuela Foletto, Annibale Biggeri, Luigi Montano
{"title":"[生活在PFAS污染地区的青年男子的生殖健康：计划中的临时数据分析]。","authors":"Francesco Bertola, Salvatore Micali, Marco Ticonosco, Enrico Ioverno, Enzo Dal Lago, Andrea Busolo, Rafael Ramirez Morales, Grazia Buonfantino, Alessandro Di Giorgi, Francesco Paolo Busardò, Katsiaryna Nikitsenka, Giuliana Ruggero, Michela Zamboni, Giuliano Fin, Emanuela Foletto, Annibale Biggeri, Luigi Montano","doi":"10.19191/EP25.1.A843.014","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>to evaluate the association between exposure to per- and polyfluoroalkyl substances (PFAS) and semen quality in young adulthood, with particular attention to different exposure metrics: serum and seminal concentrations of perfluorooctanoic acid (PFOA) and perfluorosulfonic acid (PFOS), foetal exposure, duration of exposure.</p><p><strong>Design: </strong>cross-sectional study.</p><p><strong>Setting and participants: </strong>1,000 subjects aged 18-35 years residing in the Veneto area with water contamination by PFAS, enrolled in the period 2022-2023; this interim analysis involves 507 subjects out of the 1,000 enrolled.</p><p><strong>Main outcomes measures: </strong>only the 2 main semen parameters were considered: sperm count, motility and morphology.</p><p><strong>Results: </strong>from this interim analysis an association between sperm motility and morphology and duration of residence emerges: OR 1.14 (90%CI 0.99; 1.31) p=0.065 (an age-matched conditional logistic regression tested the linear trend between duration of residence in years and presence/absence of alterations in motility <42% or morphology <4% of the spermatozoa).</p><p><strong>Conclusions: </strong>these results strengthen the literature on reproductive health risks related to exposure to PFAS and in particular to PFOA and PFOS. They also highlight the importance of duration of exposure and exposure starting from foetal life. The study here presented is part of a larger project still underway regarding analytical determinations on the biological samples provided. It was possible to anticipate the results of the interim analysis on 507 subjects out of the 1,000 enrolled.</p>","PeriodicalId":50511,"journal":{"name":"Epidemiologia & Prevenzione","volume":"49 1","pages":"63-73"},"PeriodicalIF":1.2000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Reproductive health of young men living in PFAS contaminated areas: planned ad-interim data analysis].\",\"authors\":\"Francesco Bertola, Salvatore Micali, Marco Ticonosco, Enrico Ioverno, Enzo Dal Lago, Andrea Busolo, Rafael Ramirez Morales, Grazia Buonfantino, Alessandro Di Giorgi, Francesco Paolo Busardò, Katsiaryna Nikitsenka, Giuliana Ruggero, Michela Zamboni, Giuliano Fin, Emanuela Foletto, Annibale Biggeri, Luigi Montano\",\"doi\":\"10.19191/EP25.1.A843.014\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>to evaluate the association between exposure to per- and polyfluoroalkyl substances (PFAS) and semen quality in young adulthood, with particular attention to different exposure metrics: serum and seminal concentrations of perfluorooctanoic acid (PFOA) and perfluorosulfonic acid (PFOS), foetal exposure, duration of exposure.</p><p><strong>Design: </strong>cross-sectional study.</p><p><strong>Setting and participants: </strong>1,000 subjects aged 18-35 years residing in the Veneto area with water contamination by PFAS, enrolled in the period 2022-2023; this interim analysis involves 507 subjects out of the 1,000 enrolled.</p><p><strong>Main outcomes measures: </strong>only the 2 main semen parameters were considered: sperm count, motility and morphology.</p><p><strong>Results: </strong>from this interim analysis an association between sperm motility and morphology and duration of residence emerges: OR 1.14 (90%CI 0.99; 1.31) p=0.065 (an age-matched conditional logistic regression tested the linear trend between duration of residence in years and presence/absence of alterations in motility <42% or morphology <4% of the spermatozoa).</p><p><strong>Conclusions: </strong>these results strengthen the literature on reproductive health risks related to exposure to PFAS and in particular to PFOA and PFOS. 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It was possible to anticipate the results of the interim analysis on 507 subjects out of the 1,000 enrolled.</p>\",\"PeriodicalId\":50511,\"journal\":{\"name\":\"Epidemiologia & Prevenzione\",\"volume\":\"49 1\",\"pages\":\"63-73\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epidemiologia & Prevenzione\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.19191/EP25.1.A843.014\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiologia & Prevenzione","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.19191/EP25.1.A843.014","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
[Reproductive health of young men living in PFAS contaminated areas: planned ad-interim data analysis].
Objectives: to evaluate the association between exposure to per- and polyfluoroalkyl substances (PFAS) and semen quality in young adulthood, with particular attention to different exposure metrics: serum and seminal concentrations of perfluorooctanoic acid (PFOA) and perfluorosulfonic acid (PFOS), foetal exposure, duration of exposure.
Design: cross-sectional study.
Setting and participants: 1,000 subjects aged 18-35 years residing in the Veneto area with water contamination by PFAS, enrolled in the period 2022-2023; this interim analysis involves 507 subjects out of the 1,000 enrolled.
Main outcomes measures: only the 2 main semen parameters were considered: sperm count, motility and morphology.
Results: from this interim analysis an association between sperm motility and morphology and duration of residence emerges: OR 1.14 (90%CI 0.99; 1.31) p=0.065 (an age-matched conditional logistic regression tested the linear trend between duration of residence in years and presence/absence of alterations in motility <42% or morphology <4% of the spermatozoa).
Conclusions: these results strengthen the literature on reproductive health risks related to exposure to PFAS and in particular to PFOA and PFOS. They also highlight the importance of duration of exposure and exposure starting from foetal life. The study here presented is part of a larger project still underway regarding analytical determinations on the biological samples provided. It was possible to anticipate the results of the interim analysis on 507 subjects out of the 1,000 enrolled.
期刊介绍：
Epidemiologia & Prevenzione, oggi organo della Associazione italiana di epidemiologia, raccoglie buona parte delle migliori e originali esperienze italiane di ricerca epidemiologica e di studio degli interventi per la prevenzione e la sanità pubblica.
La rivista – indicizzata su Medline e dotata di Impact Factor – è un canale importante anche per la segnalazione al pubblico internazionale di contributi che altrimenti circolerebbero soltanto in Italia.
E&P in questi decenni ha svolto una funzione di riferimento per la sanità pubblica ma anche per i cittadini e le loro diverse forme di aggregazione. Il principio che l’ha ispirata era, e rimane, che l’epidemiologia ha senso se è funzionale alla prevenzione e alla sanità pubblica e che la prevenzione ha ben poche possibilità di realizzarsi se non si fonda su valide basi scientifiche e se non c’è la partecipazione di tutti i soggetti interessati.
Modalità di comunicazione aggiornate, metodologia statistica ed epidemiologica rigorosa, validità degli studi e solidità delle interpretazioni dei risultati sono la solida matrice su cui E&P è costruita. A questa si accompagna una forte responsabilità etica verso la salute pubblica, che oggi ha ampliato in forma irreversibile il suo orizzonte, e include in forma sempre più consapevole non solo gli esseri umani, ma l’intero pianeta e le modificazioni che l’uomo apporta all’universo in cui vive.
L’ambizione è che l’offerta di nuovi strumenti di comunicazione, informazione e formazione, soprattutto attraverso l''uso di internet, renda la rivista non solo un tradizionale veicolo di contenuti e analisi scientifiche, ma anche un potente strumento a disposizione di una comunità di interessi e di valori che ha a cuore la salute pubblica.
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