Muktesh Mohan, Oana-Maria Thoma, Shivani Sharma, Gargi Sharma, Markus F Neurath, Maximillian Waldner, Kanwarpal Singh
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Longitudinal Monitoring of Inflammatory Bowel Disease in Mice Using Endoscopic Optical Coherence Tomography.
Background: Inflammatory bowel disease (IBD) is one of the fastest-growing diseases globally. Nearly 5 million people are affected by IBD, with an incremental growth rate of 47.45% between 1990 and 2019.
Aim and methods: We aim to provide a noninvasive approach to detecting IBD with an in-house developed 1310 nm endoscopic optical coherence tomography (OCT) system. Mice with acute colitis underwent a longitudinal colon imaging process for real-time and long-run disease progression. The OCT images were processed and segmented using a computer vision image processing-based segmentation algorithm for further thickness mapping and attenuation coefficient calculations.
Result: An increase in overall colon wall thickness due to inflammation was observed, as well as a reduction in attenuation coefficient due to a change in refractive index.
Conclusion: Comparable results with white light endoscope and histological examination suggest the clinical potential of the 1310 nm endoscopic OCT system for in vivo assessment of IBD.
期刊介绍：
Inflammatory Bowel Diseases® supports the mission of the Crohn''s & Colitis Foundation by bringing the most impactful and cutting edge clinical topics and research findings related to inflammatory bowel diseases to clinicians and researchers working in IBD and related fields. The Journal is committed to publishing on innovative topics that influence the future of clinical care, treatment, and research.
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