免疫学研究中的一个重要疏忽：小鼠模型中补体缺陷的普遍性

IF 4.5 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2025-03-12 DOI:10.1002/eji.202451678

África González-Fernández

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引用次数: 0

摘要

补体系统是先天免疫反应的重要组成部分，在保护身体免受病原体侵害和维持体内平衡方面起着至关重要的作用。这种复杂的蛋白质网络作为第一道防线，增强抗体和吞噬细胞清除微生物和受损细胞的能力。它还参与炎症过程和白细胞募集。然而，关于小鼠品系补体组分C5的常见突变的发现引起了对许多免疫学研究的有效性的关注，包括传染病、炎症、自身免疫性疾病和癌症研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A Critical Oversight in Immunology Research: The Prevalence of Complement Deficiencies in Mouse Models

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A Critical Oversight in Immunology Research: The Prevalence of Complement Deficiencies in Mouse Models

The complement system is a crucial component of the innate immune response, playing a vital role in defending the body against pathogens and maintaining homeostasis. This complex network of proteins acts as a first line of defense, enhancing the ability of antibodies and phagocytic cells to clear microbes and damaged cells. It also participates in inflammation processes and leukocyte recruitment. However, findings regarding a common mutation in the complement component C5 in mouse strains have raised concerns about the validity of numerous studies in immunology, including infectious diseases, inflammatory, autoimmune disorders, and cancer research.

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.