银屑病关节炎患者的绒毛吸收

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-03-07 DOI:10.1016/j.semarthrit.2025.152701

Fadi Kharouf , Shangyi Gao , Daniel Pereira , Cheryl F Rosen , Richard J Cook , Vinod Chandran , Dafna D Gladman

{"title":"银屑病关节炎患者的绒毛吸收","authors":"Fadi Kharouf , Shangyi Gao , Daniel Pereira , Cheryl F Rosen , Richard J Cook , Vinod Chandran , Dafna D Gladman","doi":"10.1016/j.semarthrit.2025.152701","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Tuft resorption (TR) is an important radiographic feature of psoriatic arthritis (PsA). We aimed to define the prevalence of TR in patients with PsA, the clinical and radiographic features associated with it, and the risk factors for its occurrence.</div></div><div><h3>Methods</h3><div>We included patients with PsA followed at our prospective observational cohort. We defined TR as resorptive changes in the terminal tufts of the fingers or toes. We used generalized estimating equations to characterize clinical and radiographic features cross-sectionally associated with TR. We used multivariate Cox regression analysis to identify factors associated with the development of TR.</div></div><div><h3>Results</h3><div>Of the 1303 patients included in the study, 526 (40.4 %) were observed to have TR, of whom 181 (34.4 %) developed it during follow-up. TR was associated with older age (OR 1.49, <em>p</em> < 0.01), longer duration of PsA (OR 1.03, <em>p</em> < 0.01), higher radiographic damaged joint count (OR 1.02, <em>p</em> = 0.04), axial disease (OR 1.73, <em>p</em> < 0.01), and the number of systemic disease-modifying anti-rheumatic drugs (DMARDs) used (OR 1.27, <em>p</em> < 0.01). Male sex (HR 1.54, <em>p</em> = 0.01), vertebral osteopenia (HR 1.39, <em>p</em> = 0.02), and use of non-steroidal anti-inflammatory drugs (HR 1.43, <em>p</em> = 0.03) were associated with the development of TR. Use of biologic and targeted synthetic DMARDs was protective (HR 0.70, <em>p</em> = 0.05), although not significant at the 5 % level.</div></div><div><h3>Conclusion</h3><div>TR is a common radiographic feature of PsA. It is associated with more severe disease, including peripheral and axial radiographic damage.</div></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"72 ","pages":"Article 152701"},"PeriodicalIF":4.6000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tuft resorption in patients with psoriatic arthritis\",\"authors\":\"Fadi Kharouf , Shangyi Gao , Daniel Pereira , Cheryl F Rosen , Richard J Cook , Vinod Chandran , Dafna D Gladman\",\"doi\":\"10.1016/j.semarthrit.2025.152701\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Tuft resorption (TR) is an important radiographic feature of psoriatic arthritis (PsA). We aimed to define the prevalence of TR in patients with PsA, the clinical and radiographic features associated with it, and the risk factors for its occurrence.</div></div><div><h3>Methods</h3><div>We included patients with PsA followed at our prospective observational cohort. We defined TR as resorptive changes in the terminal tufts of the fingers or toes. We used generalized estimating equations to characterize clinical and radiographic features cross-sectionally associated with TR. We used multivariate Cox regression analysis to identify factors associated with the development of TR.</div></div><div><h3>Results</h3><div>Of the 1303 patients included in the study, 526 (40.4 %) were observed to have TR, of whom 181 (34.4 %) developed it during follow-up. TR was associated with older age (OR 1.49, <em>p</em> < 0.01), longer duration of PsA (OR 1.03, <em>p</em> < 0.01), higher radiographic damaged joint count (OR 1.02, <em>p</em> = 0.04), axial disease (OR 1.73, <em>p</em> < 0.01), and the number of systemic disease-modifying anti-rheumatic drugs (DMARDs) used (OR 1.27, <em>p</em> < 0.01). Male sex (HR 1.54, <em>p</em> = 0.01), vertebral osteopenia (HR 1.39, <em>p</em> = 0.02), and use of non-steroidal anti-inflammatory drugs (HR 1.43, <em>p</em> = 0.03) were associated with the development of TR. Use of biologic and targeted synthetic DMARDs was protective (HR 0.70, <em>p</em> = 0.05), although not significant at the 5 % level.</div></div><div><h3>Conclusion</h3><div>TR is a common radiographic feature of PsA. It is associated with more severe disease, including peripheral and axial radiographic damage.</div></div>\",\"PeriodicalId\":21715,\"journal\":{\"name\":\"Seminars in arthritis and rheumatism\",\"volume\":\"72 \",\"pages\":\"Article 152701\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in arthritis and rheumatism\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0049017225000721\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in arthritis and rheumatism","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0049017225000721","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的银屑病关节炎（PsA）的影像学特征之一是骨吸收（TR）。我们的目的是确定PsA患者中TR的患病率，与之相关的临床和影像学特征，以及其发生的危险因素。方法我们纳入前瞻性观察队列的PsA患者。我们将TR定义为手指或脚趾末端的吸收性改变。我们使用广义估计方程来表征与TR相关的临床和影像学特征。我们使用多变量Cox回归分析来确定与TR发展相关的因素。结果在纳入研究的1303例患者中，526例（40.4%）被观察到患有TR，其中181例（34.4%）在随访期间发展为TR。TR与年龄较大相关(OR 1.49, p <；0.01)， PsA持续时间较长(OR 1.03, p <；0.01)，较高的x线片损伤关节计数（OR 1.02, p = 0.04），轴向疾病(OR 1.73, p <；0.01)，使用全身疾病改善抗风湿药物（DMARDs）的数量(OR 1.27, p <；0.01)。男性（HR 1.54, p = 0.01）、椎体骨质减少（HR 1.39, p = 0.02）和使用非甾体抗炎药（HR 1.43, p = 0.03）与TR的发生有关。使用生物制剂和靶向合成dmard具有保护作用（HR 0.70, p = 0.05），尽管在5%的水平上不显著。结论tr是PsA的常见影像学特征。它与更严重的疾病相关，包括周围和轴向放射损害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Tuft resorption in patients with psoriatic arthritis

Objectives

Tuft resorption (TR) is an important radiographic feature of psoriatic arthritis (PsA). We aimed to define the prevalence of TR in patients with PsA, the clinical and radiographic features associated with it, and the risk factors for its occurrence.

Methods

We included patients with PsA followed at our prospective observational cohort. We defined TR as resorptive changes in the terminal tufts of the fingers or toes. We used generalized estimating equations to characterize clinical and radiographic features cross-sectionally associated with TR. We used multivariate Cox regression analysis to identify factors associated with the development of TR.

Results

Of the 1303 patients included in the study, 526 (40.4 %) were observed to have TR, of whom 181 (34.4 %) developed it during follow-up. TR was associated with older age (OR 1.49, p < 0.01), longer duration of PsA (OR 1.03, p < 0.01), higher radiographic damaged joint count (OR 1.02, p = 0.04), axial disease (OR 1.73, p < 0.01), and the number of systemic disease-modifying anti-rheumatic drugs (DMARDs) used (OR 1.27, p < 0.01). Male sex (HR 1.54, p = 0.01), vertebral osteopenia (HR 1.39, p = 0.02), and use of non-steroidal anti-inflammatory drugs (HR 1.43, p = 0.03) were associated with the development of TR. Use of biologic and targeted synthetic DMARDs was protective (HR 0.70, p = 0.05), although not significant at the 5 % level.

Conclusion

TR is a common radiographic feature of PsA. It is associated with more severe disease, including peripheral and axial radiographic damage.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.