A curriculum learning approach to training antibody language models.

There is growing interest in pre-training antibody language models (AbLMs) with a mixture of unpaired and natively paired sequences, seeking to combine the proven benefits of training with natively paired sequences with the massive scale of unpaired antibody sequence datasets. However, given the novelty of this strategy, the field lacks a systematic evaluation of data processing methods and training strategies that maximize the benefits of mixed training data while accommodating the significant imbalance in the size of existing paired and unpaired datasets. Here we introduce a method of curriculum learning for AbLMs, which facilitates a gradual transition from unpaired to paired sequences during training. We optimize this method and show that a 650M-parameter curriculum model, CurrAb, outperforms existing mixed AbLMs in downstream classification tasks.