乌干达出现COVID-19样症状患者的COVID-19疫苗接种状况及相关因素

Sylvia Kusemererwa, Violet Ankunda, Terry A Ongaria, Andrew Abaasa, Ayoub Kakande, Deogratius Ssemwanga, Geofrey Kimbugwe, Bernadette Nayiga, Henry K Bosa, Alfred Driwale, Yonas T Woldemariam, Annet Kisakye, James Humphreys, Archibald K Worwui, Sandra Cohuet, Jason M Mwenda, Alison M Elliott, Pontiano Kaleebu, Eugene Ruzagira
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引用次数: 0

摘要

新的SARS-CoV-2变体的出现威胁到全球疫苗接种运动的有效性。本研究调查了乌干达19个医疗机构中出现covid -19样症状的患者的疫苗接种状况和相关因素。材料和方法:利用在卫生机构收集的数据进行了横断面分析,以评估2023年3月至2024年3月乌干达COVID-19疫苗的有效性。参与者是具有covid -19样症状的12岁及以上的个体,他们在症状出现后10天内进行了SARS-CoV-2 qPCR检测。该研究包括获得知情同意,收集病史和疫苗接种史(使用疫苗接种卡和卫生部COVID-19数据库确认),进行体检,填写问卷,并采取口腔/鼻咽拭子进行SARS-CoV-2 qPCR检测。疫苗接种覆盖率定义为接种至少一剂疫苗。Logistic回归用于确定与疫苗接种状况相关的因素。结果:在1398名参与者中(55.4%为女性),中位年龄为30.0岁(IQR: 24.0-41.0)。疫苗接种率为66.6%。与首都坎帕拉相比,居住在Wakiso区与更高的疫苗接种可能性相关(校正优势比[aOR] = 1.4, 95% CI: 1.0-1.8, p = 0.021)。一线和卫生保健工作者更有可能接种疫苗(aOR = 5.0, 95% CI: 3.6-7.3, p)。结论:我们的研究结果强调需要有针对性的公共卫生信息和支持,以促进疫苗接种,特别是在非卫生保健工作者中。解决这些差距对于保持高疫苗接种覆盖率和减轻新的SARS-CoV-2变体对人口的影响至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID-19 vaccination status and associated factors among patients presenting with COVID-19-like symptoms in Uganda.

Introduction: The emergence of new SARS-CoV-2 variants threatens the effectiveness of global vaccination campaigns. This study examines the vaccination status and associated factors among patients presenting with COVID-19-like symptoms at 19 healthcare facilities in Uganda.

Materials and methods: A cross-sectional analysis was conducted using data collected at health facilities to evaluate the effectiveness of COVID-19 vaccines in Uganda from March 2023 to March 2024. Participants were individuals aged 12 years and older with COVID-19-like symptoms who underwent a SARS-CoV-2 qPCR test within 10 days of symptom onset. The study involved obtaining informed consent, collecting medical and vaccination histories (confirmed using vaccination cards and Ministry of Health COVID-19 database), performing physical examinations, administering a questionnaire, and taking oral/nasopharyngeal swabs for SARS-CoV-2 qPCR testing. Vaccination coverage was defined as receiving at least one vaccine dose. Logistic regression was used to identify factors associated with vaccination status.

Results: Among 1398 participants enrolled (55.4 % female), the median age was 30.0 years (IQR: 24.0-41.0). Vaccination coverage, was 66.6 %. Residing in Wakiso district compared to the Capital, Kampala was associated with a higher likelihood of vaccination (adjusted odds ratio [aOR] = 1.4, 95 % CI: 1.0-1.8, p = 0.021). Frontline and healthcare workers were more likely to be vaccinated (aOR = 5.0, 95 % CI: 3.6-7.3, p < 0.001), as were individuals with a previous COVID-19 diagnosis (aOR = 2.4, 95 % CI: 1.6-3.9, p < 0.001).

Conclusions: Our results underscore the need for targeted public health messaging and support to promote vaccination, especially among non-healthcare workers. Addressing these gaps is crucial for maintaining high vaccination coverage and mitigating the impact of new SARS-CoV-2 variants on the population.

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