稳定型冠心病不同表型患者肿瘤坏死因子-α、血管内皮生长因子及miRNA-145的表达

IF 0.5 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Kardiologiya Pub Date : 2025-02-28 DOI:10.18087/cardio.2025.2.n2837

A O Yusupova, O A Slepova, N N Pakhtusov, M I Kalinina, E V Privalova, Yu N Belenkov

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引用次数: 0

摘要

目的探讨miR-145、肿瘤坏死因子α (TNF-α)、血管内皮生长因子（VEGF）在缺血性心脏病（IHD）及不同冠脉疾病（CAD）、阻塞性和非阻塞性表型患者中的表达水平。材料和方法本横断面观察性研究纳入107例年龄45-75岁确诊为稳定IHD的患者。根据冠状动脉造影或多层螺旋ct资料，将患者分为无冠状动脉阻塞组（NOCA， 51例）和有冠状动脉阻塞组（OCA， 56例）。在NOCA组中，女性占多数（62.5%），而在OCA患者中，男性占多数（67.9%）。检测两组患者VEGF、TNF-α浓度及miRNA-145表达。结果NOCA组VEGF （p=0.004）、TNF-α (p=0.002)浓度及miRNA-145表达量显著升高（p=0.014）。在该组中，miRNA-145浓度与VEGF浓度相关(ρ=0.442；p=0.013)和TNF-α (ρ=-0.386；p = 0.032)。在OCA组中，TNF-α和VEGF浓度之间存在相关性(ρ=0.645；p < 0.001)、miRNA-145和VEGF (ρ=0.584；p<0.001)， miRNA-145c和TNF-α (ρ=0.421；术中,0.001)。单因素logistic回归分析显示，miRNA-145表达和女性性别是影响CAD型的显著因素。构建具有统计学意义的ROC曲线评价miRNA-145的诊断能力。结论NOCA组miRNA-145的表达水平最高。ROC分析显示，miRNA-145表达水平高于1.084 REU可能是稳定型IHD患者NOCA表型存在的一个因素。低水平的miRNA-145表达可能与更严重的动脉粥样硬化性CAD相关。

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Tumor Necrosis Factor-α, Vascular Endothelial Growth Factor and miRNA-145 Expression in Patients With Different Phenotypes of Stable Coronary Artery Disease.

Aim To evaluate the expression level of miR-145, tumor necrosis factor α (TNF-α), and vascular endothelial growth factor (VEGF) in patients with ischemic heart disease (IHD) and different, obstructive and non-obstructive, phenotypes of coronary artery disease (CAD).Material and methods This cross-sectional observational study included 107 patients aged 45-75 years with a verified diagnosis of stable IHD. Based on the data of coronary angiography or spiral multislice computed tomography of CA, the patients were divided into two groups, with no obstructive (NOCA, 51 patients) and with obstructive coronary artery (OCA, 56 patients). In the NOCA group, women predominated (62.5%), while among patients with OCA, men predominated (67.9%). Concentrations of VEGF and TNF-α and miRNA-145 expression were measured in patients of both groups.Results In the NOCA group, the concentrations of VEGF (p=0.004) and TNF-α (p=0.002) and the miRNA-145 expression (p=0.014) were significantly higher. In this group, the miRNA-145 concentration was correlated with the concentrations of VEGF (ρ=0.442; p=0.013) and TNF-α (ρ=-0.386; p=0.032). In the OCA group, correlations were found between the concentrations of TNF-α and VEGF (ρ=0.645; p<0.001), miRNA-145 and VEGF (ρ=0.584; p<0.001), and miRNA-145c and TNF-α (ρ=0.421; p<0.001). According to the univariate logistic regression analysis, significant factors for the CAD type were miRNA-145 expression and female gender. A statistically significant ROC curve was constructed to evaluate the diagnostic capability of miRNA-145.Conclusion According to the study results, the highest level of miRNA-145 expression was found in the NOCA group. The ROC analysis showed that a level of miRNA-145 expression higher than 1.084 REU can be a factor of the NOCA phenotype presence in patients with stable IHD. A lower level of miRNA-145 expression can be associated with more severe atherosclerotic CAD.

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来源期刊

Kardiologiya 医学-心血管系统

CiteScore

1.70

自引率

20.00%

发文量

审稿时长

3-8 weeks

期刊介绍： “Kardiologiya” (Cardiology) is a monthly scientific, peer-reviewed journal committed to both basic cardiovascular medicine and practical aspects of cardiology. As the leader in its field, “Kardiologiya” provides original coverage of recent progress in cardiovascular medicine. We publish state-of-the-art articles integrating clinical and research activities in the fields of basic cardiovascular science and clinical cardiology, with a focus on emerging issues in cardiovascular disease. Our target audience spans a diversity of health care professionals and medical researchers working in cardiovascular medicine and related fields. The principal language of the Journal is Russian, an additional language – English (title, authors’ information, abstract, keywords). “Kardiologiya” is a peer-reviewed scientific journal. All articles are reviewed by scientists, who gained high international prestige in cardiovascular science and clinical cardiology. The Journal is currently cited and indexed in major Abstracting & Indexing databases: Web of Science, Medline and Scopus. The Journal''s primary objectives Contribute to raising the professional level of medical researchers, physicians and academic teachers. Present the results of current research and clinical observations, explore the effectiveness of drug and non-drug treatments of heart disease, inform about new diagnostic techniques; discuss current trends and new advancements in clinical cardiology, contribute to continuing medical education, inform readers about results of Russian and international scientific forums; Further improve the general quality of reviewing and editing of manuscripts submitted for publication; Provide the widest possible dissemination of the published articles, among the global scientific community; Extend distribution and indexing of scientific publications in major Abstracting & Indexing databases.