靶向Wnt通路治疗膝关节骨关节炎。

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-02-25 DOI:10.1016/j.semarthrit.2025.152662

Nancy E. Lane

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引用次数: 0

摘要

骨性关节炎的流行病学和临床前模型都强有力地支持Wnt信号通路的调节作为疼痛性膝骨性关节炎的可药物靶点。本文回顾了使用Wnt信号调节剂治疗膝关节OA的临床研究，并提出了早期研究疾病和长期治疗的建议。

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Targeting the Wnt pathway for the treatment of Osteoarthritis of the knee

Both epidemiologic and preclinical models of OA provide strong support for modulation of the Wnt signaling pathway as a druggable target for painful knee OA. This paper reviews the clinical studies that have been performed with Wnt signaling modulating agents for knee OA treatment and makes recommendations to study earlier disease and administer treatments for a longer duration.

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.